Results 81 to 90 of about 10,507 (197)

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

An explainable artificial intelligence approach for predicting cardiovascular outcomes using electronic health records.

PLOS Digital Health, 2022
Understanding the conditionally-dependent clinical variables that drive cardiovascular health outcomes is a major challenge for precision medicine.
Sergiusz Wesołowski, Gordon Lemmon, Edgar J Hernandez, Alex Henrie, Thomas A Miller, Derek Weyhrauch, Michael D Puchalski, Bruce E Bray, Rashmee U Shah, Vikrant G Deshmukh, Rebecca Delaney, H Joseph Yostl, Karen Eilbeck, Martin Tristani-Firouzi, Mark Yandell   +14 more
doaj   +1 more source

Estudio del sistema de marcapasos auriculares en el corazón del perro [PDF]

, 1998
Inclou referències ...
Bethencourt, Armando, Ferreira, Ignacio, Gómez Jaume, Alfredo, Palou, Andreu, Pastelin, Gustavo   +4 more
core  

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Temporary neonatal atrial pacing through the umbilical venous route: A novel technique

Annals of Pediatric Cardiology, 2011
Atrial pacing in the neonate is rarely done due to constraints of equipment, technical knowhow, and risk of complications. We describe a novel method of atrial pacing in the new born using equipment readily available in any intensive care unit.
Hiren N Doshi, Seema T Lokare
doaj   +1 more source

Correlation Analysis of 24‐h Minimum Heart Rate Levels and Deceleration Capacity of Heart Rate in Patients With Type 2 Diabetes Mellitus Complicated With Essential Hypertension

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
Sex‐specific 24‐hour minimum heart rate (MHR) stratification in patients with type 2 diabetes mellitus and essential hypertension (T2DM‐EH). Three key findings are shown from subgroup analysis: (1) In the normal MHR group (Group B), advancing age independently predicts reduced deceleration capacity (DC) in both sexes.
Pingping Wu, Zhengrong Xu, Xiuyu Zheng, Linying Gong, Hongkun Qiao, Guoyan Xu, Qunfang Xie   +6 more
wiley   +1 more source

Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels [PDF]

Cell, 2000
Voltage-gated L-type Ca2+ channels (LTCCs) containing a pore-forming alpha1D subunit (D-LTCCs) are expressed in neurons and neuroendocrine cells. Their relative contribution to total L-type Ca2+ currents and their physiological role and significance as a drug target remain unknown.
PLATZER J, ENGEL J, SCHROTT FISCHER A, STEPHAN K, BOVA, SERGIO, CHEN H, ZHENG H, STRIESSNIG J.   +7 more
openaire   +3 more sources

Pulsed Field Ablation for Atrial Fibrillation in Patients With Obesity: Procedural and Clinical Outcomes

Pacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 636-643, May 2026.
ABSTRACT Background Procedural and clinical outcomes in patients with obesity undergoing catheter ablation for atrial fibrillation (AF) have been mixed. Clinical data in the context of pulsed field ablation (PFA) are currently limited in this patient cohort.
Francis J. Ha, Duron Prinsloo, Edwin Xu, Hui Chen Han, Nitesh Nerlekar, Adam J. Brown, Emily Kotschet   +6 more
wiley   +1 more source

Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity

The Journal of Physiology, Volume 604, Issue 9, Page 3504-3512, 1 May 2026.
Abstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
Eilidh A. MacDonald, T. Alexander Quinn
wiley   +1 more source