Results 81 to 90 of about 972,180 (179)

Aerobic Endurance Training Modulates Cardiac Renin‐Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT To investigate the involvement of metalloproteinases (MMPs) in the context of endurance training and their interactions with renin‐angiotensin signalling (RAS) in stress‐induced pathophysiological responses. Trained rats were submitted to 8‐weeks of endurance treadmill training with chronic mild stress (CMS), TS rats, and without CMS (T).
Vinicius Guzzoni, Fabiana Gomes Ferreira, Lívia Bruni de Souza, Rebecca Salomão, Nicholas Kesler, Rodrigo Yokota, Nilsa Regina Damaceno‐Rodrigues, Elia Garcia Caldini, Fernanda Klein Marcondes, Rita de Cássia Marqueti, Steven T. Haller, David J. Kennedy, Lauren G. Koch, Dulce Elena Casarini, Tatiana Sousa Cunha   +14 more
wiley   +1 more source

Molecular pathway for the localized formation of the sinoatrial node.

, 2007
The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat.
Harvey, RP, Clout, DE, Mommersteeg, MT, Christoffels, VM, Hoogaars, WM, Wiese, C, de Gier-de Vries, C, Papaioannou, VE, Brown, NA, Prall, OW, Moorman, AF   +10 more
core   +2 more sources

Clinical characteristics and follow-up of complex arrhythmias associated with RYR2 gene mutations in children

Frontiers in Genetics
ObjectiveThe aim of this study was to analyze the diagnosis, treatment, and follow-up of six cases of complex arrhythmias associated with RYR2 gene mutations in children.MethodA retrospective analysis was conducted on six children diagnosed with complex ...
Yefeng Wang, Yufan Yang, Ningan Xu, Yunbin Xiao, Chao Zuo, Zhi Chen   +5 more
doaj   +1 more source

CAROTID ARTERY STENTING IN A PATIENT WITH SINUS BRADYCARDIA: CLINICAL CASE

Рациональная фармакотерапия в кардиологии, 2018
Syndrome of hemodynamic depression is a frequent complication of the carotid artery endovascular intervention and, as a rule, is transient in nature. This article presents a clinical case of carotid artery stenting in a 63-year-old patient.
E. S. Bulgakova, T. V. Tvorogova, B. A. Rudenko, O. M. Drapkina   +3 more
doaj   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, Volume 604, Issue 16, Page 6691-6703, 15 August 2026.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Ageing-related changes of connexins and conduction within the sinoatrial node

, 2004
Clinical studies have shown that sinoatrial node dysfunction occurs at the highest incidence in the elderly population. Guinea-pigs were studied throughout their lifespan (i.e.
Jones, Sandra A., Lancaster, Matthew K., Boyett, Mark R.   +2 more
core   +1 more source

Comparative study of sinoatrial node morphology and innervation [PDF]

, 2016
[...]. Aim of and objectives of the study. The aim of the study: to identify limits and innervation of the sinoatrial node in hearts of mice, rabbits and pigs. Objectives: 1. To examine the distribution of pacemaker cells within the right atrium. 2.
Inokaitis, Hermanas
core  

SCN5A and sinoatrial node pacemaker function

, 2007
The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na ...
Zhang, Henggui, Grace, Andrew A., Lei, Ming, Huang, Christopher L H   +3 more
core   +1 more source

Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the SCN5A-E161K Mutation and Role of the H558R Polymorphism

Frontiers in Physiology, 2018
Background: Carriers of the E161K mutation in the SCN5A gene, encoding the NaV1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (INa), show sinus bradycardia and occasional exit block.
Ronald Wilders
doaj   +1 more source

One-dimensional rabbit sinoatrial node models: benefits and limitations

, 2003
INTRODUCTION: Cardiac multicellular modeling has traditionally focused on ventricular electromechanics. More recently, models of the atria have started to emerge, and there is much interest in addressing sinoatrial node structure and function.
Garny, A, Hunter, PJ, Boyett, MR, Kohl, P, Noble, D, Noble, Denis   +5 more
core   +1 more source