Results 71 to 80 of about 5,596 (157)

Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains

JCI Insight, 2022
Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP.
Lu Ren, Phung N. Thai, Raghavender Reddy Gopireddy, Valeriy Timofeyev, Hannah A. Ledford, Ryan L. Woltz, Seojin Park, Jose L. Puglisi, Claudia M. Moreno, Luis Fernando Santana, Alana C. Conti, Michael I. Kotlikoff, Yang Kevin Xiang, Vladimir Yarov-Yarovoy, Manuela Zaccolo, Xiao-Dong Zhang, Ebenezer N. Yamoah, Manuel F. Navedo, Nipavan Chiamvimonvat   +18 more
doaj   +1 more source

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart

Frontiers in Physiology, 2020
The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age, resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults.
Aaazh M. Alghamdi, Aaazh M. Alghamdi, Mark R. Boyett, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang   +7 more
doaj   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, Volume 604, Issue 9, Page 3672-3693, 1 May 2026.
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Short‐term effects of weight‐loading on heart rate variability in obese adults

Physiological Reports, Volume 14, Issue 10, May 2026.
Abstract Weight‐loading reduces body fat, but its effects on cardiac autonomic modulation remain unclear. We examined heart rate variability (HRV) during free‐living weight‐loading in adults with class I obesity. Fifty‐one participants (27 females) were randomized to wear a heavy (11% of body weight) or a light vest (1%) for 8 h/day for 15 days. Twenty‐
Jakob Bellman, Per‐Anders Jansson, John‐Olov Jansson, Claes Ohlsson, Lennart Bergfeldt   +4 more
wiley   +1 more source

Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the SCN5A-E161K Mutation and Role of the H558R Polymorphism

Frontiers in Physiology, 2018
Background: Carriers of the E161K mutation in the SCN5A gene, encoding the NaV1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (INa), show sinus bradycardia and occasional exit block.
Ronald Wilders
doaj   +1 more source

Generation of an iPSC cell line (VANYHHi001-A) from a patient with cardiac arrythmias carrying CACNA1D, SCN5A, and DSP variants

Stem Cell Research
Progressive cardiac conduction defect often associated with variants in sodium voltage-gated channel SCN5A gene and variants in the L-type calcium voltage-gated channel CACNA1D gene are implicated in sinoatrial node dysfunction.
Yvonne Sleiman, Jean-Baptiste Reisqs, Reina Bianca Tan, Frank Cecchin, Mohamed Chahine, Mohamed Boutjdir   +5 more
doaj   +1 more source

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking

Frontiers in Physiology, 2014
Normal heart rhythm (sinus rhythm) depends on regular activity of the sinoatrial node (SAN), a heterogeneous collection of specialized myocytes in the right atrium.
Sathya D Unudurthi, Roseanne M Wolf, Thomas eHund, Thomas eHund   +3 more
doaj   +1 more source

Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review

Frontiers in Cardiovascular Medicine
Sick sinus syndrome (SSS) is a grave medical condition that can precipitate sudden death. The pathogenesis of SSS remains incompletely understood. Existing research postulates that the fundamental mechanism involves increased fibrosis of the sinoatrial ...
Xinxin Shi, Xinxin Shi, Liming He, Liming He, Yucheng Wang, Yucheng Wang, Yue Wu, Yue Wu, Dongming Lin, Chao Chen, Ming Yang, Shuwei Huang, Shuwei Huang   +12 more
doaj   +1 more source

Oral theophylline corrects sinus node dysfunction in acute on chronic lithium toxicity: case report and systematic review of lithium-induced Sinus node dysfunction

Frontiers in Cardiovascular Medicine
IntroductionLithium is a well-known agent to cause systemic toxicity with its narrow therapeutic window. Toxic cardiac effects are known but seldomly reported and can manifest as sinus node dysfunction (SND) ranging from delayed conduction to sinus ...
J. Curran Henson, Lauren Morehead, Joshua Hagood, Niroshi Wijewardane, Hakan Paydak   +4 more
doaj   +1 more source

Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart

Frontiers in Physiology, 2019
Cardiovascular complications are common in type 1 diabetes mellitus (TIDM) and there is an increased risk of arrhythmias as a result of dysfunction of the cardiac conduction system (CCS). We have previously shown that, in vivo, there is a decrease in the
Yu Zhang, Yu Zhang, Yanwen Wang, Joseph Yanni, Mohammed Anwar Qureshi, Sunil Jit R. J. Logantha, Sarah Kassab, Mark R. Boyett, Natalie J. Gardiner, Hong Sun, Frank Christopher Howarth, Halina Dobrzynski   +11 more
doaj   +1 more source