Results 51 to 60 of about 975,812 (179)
The Involvement of TRPC3 channels in Sinoatrial Arrhythmias
Frontiers in Physiology, 2015 Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge.
Yue-Kun eJu +6 more
doaj +1 more source
Catheter ablation of sinoatrial node reentrant tachycardia [PDF]
, 1994 Objectives. This study evaluates 1) the safety and efficacy of catheter delivery of radiofrequency current to eliminate sustained sinoatrial node reentrant tachycardia; 2) the incident of sinoatrial node reentrant tachycardia in the current group of ...
Greenfield, Ruth Ann +5 more
core +1 more source
Российский кардиологический журнал, 2016 Resting heart rate is a strong predictor of mortality and cardiovascular outcome in patients with chronic heart failure. А specific inhibitor of the If current in the sinoatrial node ivabradine improves clinical outcome in patients with heart failure and
S. N. Tereshchenko +2 more
doaj +1 more source
Trends in research on sick sinus syndrome: A bibliometric analysis from 2000 to 2022
Frontiers in Cardiovascular Medicine, 2022 Sick sinus syndrome (SSS) is a refractory arrhythmia disease caused by the pathological changes of sinoatrial node and its adjacent tissues. 2,251 publications related to SSS were retrieved from Web of Science database from 2000 to 2022 and analyzed by ...
Xin’ai Zhang +6 more
doaj +1 more source
Insulin signaling is critical for sinoatrial node maintenance and function
Experimental and Molecular Medicine, 2023 Insulin and insulin-like growth factor 1 (IGF-1) signaling regulate cellular growth and glucose metabolism in the myocardium. However, their physiological role in the cells of the cardiac conduction system has never been explored. Therefore, we sought to
Sangmi Ock +6 more
doaj +1 more source
Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang +4 more
wiley +1 more source
Rare Case of Rapidly Worsening REM Sleep Induced Bradycardia
Case Reports in Cardiology, 2015 Sinoatrial arrest also known as sinus pause occurs when sinoatrial node of the heart transiently ceases to generate the electrical impulse necessary for the myocardium to contract. It may last from 2.0 seconds to several minutes. Etiologies of sinoatrial
Ayyappa S. Duba +6 more
doaj +1 more source
Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents
British Journal of Pharmacology, EarlyView.Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić +10 more
wiley +1 more source
Mitochondrial dysfunction on sinoatrial node and pulmonary vein electrophysiological activities
Experimental and Therapeutic Medicine, 2017 Atrial fibrillation (AF) is associated with mitochondrial dysfunction. Sinoatrial node (SAN) dysfunction increases arrhythmogenesis of pulmonary veins (PVs), which is the most important trigger of AF; however, it is not clear whether mitochondrial dysfunction differentially regulates electrical activity of SANs and PVs.
Yung-Kuo, Lin +7 more
openaire +3 more sources
Werner Irnich: Pioneer in the Development of the Dual‐Chamber Pacemaker—An Obituary
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Fifty years ago, Werner Irnich presented the concept of an optimal pacemaker capable of responding appropriately to various cardiac arrhythmias and perceptual disturbances, and intended to be used in 85% of patients. With this concept, Irnich was far ahead of his time. His proposed circuitry for AV block and atrial fibrillation, as well as his
Bernd Lemke
wiley +1 more source