The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium [PDF]
, 2009 Cardiac sodium channels are responsible for conduction in the normal and diseased heart. We aimed to investigate regional and transmural distribution of sodium channel expression and function in the myocardium.
A. A. M. Wilde +12 more
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Abnormal Ca2+ homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification [PDF]
, 2013 Ryanodine receptor type 2 (RyR2) mutations are implicated in catecholaminergic polymorphic ventricular tachycardia (CPVT) thought to result from altered myocyte Ca(2+) homeostasis reflecting inappropriate “leakiness” of RyR2-Ca(2+) release channels ...
Christopher L.-H. Huang +3 more
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The Involvement of TRPC3 channels in Sinoatrial Arrhythmias
Frontiers in Physiology, 2015 Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge.
Yue-Kun eJu +6 more
doaj +1 more source
Zdorovʹe Rebenka, 2012 In the article there are presented the data about history of development of noninvasive electrophysiological research and its application in pediatrics.
N.V. Nagornaya +2 more
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Trends in research on sick sinus syndrome: A bibliometric analysis from 2000 to 2022
Frontiers in Cardiovascular Medicine, 2022 Sick sinus syndrome (SSS) is a refractory arrhythmia disease caused by the pathological changes of sinoatrial node and its adjacent tissues. 2,251 publications related to SSS were retrieved from Web of Science database from 2000 to 2022 and analyzed by ...
Xin’ai Zhang +6 more
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The role of the calcium and the voltage clocks in sinoatrial node dysfunction. [PDF]
Yonsei Med J, 2011 Recent evidence indicates that the voltage clock (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release) jointly regulate sinoatrial node (SAN) automaticity. However, the relative importance of the voltage clock and Ca(2+) clock for pacemaking was not revealed in sick ...
Joung B, Chen PS, Lin SF.
europepmc +4 more sources
Российский кардиологический журнал, 2016 Resting heart rate is a strong predictor of mortality and cardiovascular outcome in patients with chronic heart failure. А specific inhibitor of the If current in the sinoatrial node ivabradine improves clinical outcome in patients with heart failure and
S. N. Tereshchenko +2 more
doaj +1 more source
Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation [PDF]
, 2017 Background Skin sympathetic nerve activity (SKNA) is useful for estimating sympathetic tone in humans. Objective The purpose of this study was to test the hypotheses that (1) increased SKNA is associated with the onset and termination of ...
Chen, Lan S. +9 more
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Mitochondrial dysfunction on sinoatrial node and pulmonary vein electrophysiological activities
Experimental and Therapeutic Medicine, 2017 Atrial fibrillation (AF) is associated with mitochondrial dysfunction. Sinoatrial node (SAN) dysfunction increases arrhythmogenesis of pulmonary veins (PVs), which is the most important trigger of AF; however, it is not clear whether mitochondrial dysfunction differentially regulates electrical activity of SANs and PVs.
Yung-Kuo, Lin +7 more
openaire +3 more sources
Insulin signaling is critical for sinoatrial node maintenance and function
Experimental and Molecular Medicine, 2023 Insulin and insulin-like growth factor 1 (IGF-1) signaling regulate cellular growth and glucose metabolism in the myocardium. However, their physiological role in the cells of the cardiac conduction system has never been explored. Therefore, we sought to
Sangmi Ock +6 more
doaj +1 more source