Results 41 to 50 of about 10,507 (197)

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund   +13 more
doaj   +1 more source

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction [PDF]

Journal of Interventional Cardiac Electrophysiology, 2015
The sinoatrial node (SAN) and the atrioventricular node (AVN) are the anatomical and functional regions of the heart which play critical roles in the generation and conduction of the electrical impulse. Their functions are ensured by peculiar structural cytological properties and specific collections of ion channels.
R. Milanesi, A. Bucchi, M. Baruscotti
openaire   +2 more sources

Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

JACC: Basic to Translational Science, 2018
Summary: Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the
Martin Mackasey, BSc, Emmanuel E. Egom, MD, PhD, Hailey J. Jansen, PhD, Rui Hua, PhD, Motahareh Moghtadaei, PhD, Yingjie Liu, PhD, Jaspreet Kaur, PhD, Megan D. McRae, BHSc, Oleg Bogachev, MD, Sara A. Rafferty, MSc, Gibanananda Ray, PhD, Adam W. Kirkby, MSc, Robert A. Rose, PhD   +12 more
doaj   +1 more source

Holter monitoring in patients with transient and focal ischemic attacks of the brain [PDF]

, 1986
The results of Holter monitoring in 100 patients with transient and focal cerebral ischemia were studied retrospectively. Atrial fibrillation (AF) was found in five patients compared with two from a group of 100 age and sex-matched control patients. Four
Gijn, J. (Jan) van, Kappelle, L.J. (Jaap), Klootwijk, A.P.J. (Peter), Koudstaal, P.J. (Peter), Meché, F.G.A. (Frans) van der   +4 more
core   +1 more source

Staged operation to fontan increases the incidence of sinoatrial node dysfunction [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1996
Morbidity and mortality of total cavopulmonary connection (modified Fontan procedure) may be decreased in many patients with single ventricle in whom the risk of surgery is high by performing the operations in a staged fashion. Each operative intervention, however, exposes the sinoatrial node region to risk of injury, and a multistaged approach may ...
Manning, Peter B., Mayer, John E., Wernovsky, Gil, Fishberger, Steven B., Walsh, Edward P.   +4 more
openaire   +2 more sources

A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia

Journal of Pharmacological Sciences, 2015
Although it has been reported that endotoxin-induced expression of Nox1 in the heart contributes to apoptosis in cardiomyocytes, functional role of Nox1 at the physiological expression level has not been elucidated.
Akiteru Kojima, Akio Matsumoto, Hirofumi Nishida, Yoshie Reien, Kazumi Iwata, Takeshi Shirayama, Chihiro Yabe-Nishimura, Haruaki Nakaya   +7 more
doaj   +1 more source

The Jailed Sinoatrial Node: An Interesting Case of Cardiogenic Shock Secondary to Sinus Arrest Following Percutaneous Intervention

Journal of Investigative Medicine High Impact Case Reports, 2022
Complete occlusion of the sinoatrial node artery can be a complication of percutaneous intervention (PCI) to the right coronary artery (RCA). When this happens, dysfunction of the sinus node may follow resulting in sinus arrest.
Ebubechukwu Ezeh MD, Esiemoghie Akhigbe MD, Mohammad Amro MD, Ebad Ur Rahman MD, Saad Malik MD, Kanaan Mansoor MD, Mehiar Elhamdani MD   +6 more
doaj   +1 more source

Cell-based Biological Pacemakers: Progress and Problems [PDF]

, 2018
The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases.
Ito, Hiroshi, Nakamura, Kazufumi, Saito, Yukihiro   +2 more
core   +1 more source

Familial sinoatrial node dysfunction. Increased vagal tone a possible aetiology. [PDF]

Heart, 1976
Clinical and electrophysiological studies of a 13-year-old boy with sinus bradycardia revealed sinus node dysfunction. Long-term follow-up data of members of his family indicated familial sinus node dysfucntion. Increased vagal tone was present in all patients.
D G, Caralis, P J, Varghese
openaire   +2 more sources

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

Frontiers in Physiology, 2015
The heart’s regular electrical activity is initiated by specialized cardiac pacemaker cells residing in the sinoatrial node. The rate and rhythm of spontaneous action potential firing of sinoatrial node cells are regulated by stochastic mechanisms that ...
Yael eYaniv, Kenta eTsutsui, Edward eLakatta   +2 more
doaj   +1 more source