Results 31 to 40 of about 972,180 (179)

Aging and Sinoatrial Node Dysfunction [PDF]

Circulation, 2007
In the century since the discovery by Keith and Flack of the sinoatrial node in the mole heart, a detailed mosaic of its cellular, anatomic, and electrophysiological properties has emerged. The human sinus node has been found to be anatomically constant and well localized, occupying an approximately 10-mm subepicardial region on the sulcus terminalis ...
Haris M. Haqqani, Jonathan M. Kalman
openaire   +1 more source

The role of the calcium and the voltage clocks in sinoatrial node dysfunction. [PDF]

Yonsei Med J, 2011
Recent evidence indicates that the voltage clock (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release) jointly regulate sinoatrial node (SAN) automaticity. However, the relative importance of the voltage clock and Ca(2+) clock for pacemaking was not revealed in sick ...
Joung B, Chen PS, Lin SF.
europepmc   +4 more sources

Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]

, 2021
Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
core   +2 more sources

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Ning Li, Michael A. Makara, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola, Mark E. Anderson, Peter J. Mohler, Thomas J. Hund   +13 more
doaj   +1 more source

Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

JACC: Basic to Translational Science, 2018
Summary: Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the
Martin Mackasey, BSc, Emmanuel E. Egom, MD, PhD, Hailey J. Jansen, PhD, Rui Hua, PhD, Motahareh Moghtadaei, PhD, Yingjie Liu, PhD, Jaspreet Kaur, PhD, Megan D. McRae, BHSc, Oleg Bogachev, MD, Sara A. Rafferty, MSc, Gibanananda Ray, PhD, Adam W. Kirkby, MSc, Robert A. Rose, PhD   +12 more
doaj   +1 more source

RyR2(R4496C) Expression Induces Sinoatrial Node Dysfunction [PDF]

Biophysical Journal, 2011
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is an arrhythmogenic disease characterized by stress-triggered syncope and sudden death. While ventricular tachycardia appears only during stress conditions, CPVT patients manifest basal sino-atrial node (SAN) dysfunction, but the underlying mechanism remains unknown.
Neco, Patricia, Torrente, Angelo, Zorio, Esther, Priori, Silvia G., Richard, Sylvain, Benitah, Jean-Pierre, Mangoni, Matteo, Gomez, Ana M.   +7 more
openaire   +2 more sources

The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability [PDF]

, 2021
The cardiac cycle starts when an action potential is produced by pacemaking cells in the sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million times in mice per day, imposing a monumental metabolic demand on the ...
Guarina, Laura, Grainger, Nathan, Santana, L Fernando, Cudmore, Robert H   +3 more
core   +1 more source

A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia

Journal of Pharmacological Sciences, 2015
Although it has been reported that endotoxin-induced expression of Nox1 in the heart contributes to apoptosis in cardiomyocytes, functional role of Nox1 at the physiological expression level has not been elucidated.
Akiteru Kojima, Akio Matsumoto, Hirofumi Nishida, Yoshie Reien, Kazumi Iwata, Takeshi Shirayama, Chihiro Yabe-Nishimura, Haruaki Nakaya   +7 more
doaj   +1 more source

The Jailed Sinoatrial Node: An Interesting Case of Cardiogenic Shock Secondary to Sinus Arrest Following Percutaneous Intervention

Journal of Investigative Medicine High Impact Case Reports, 2022
Complete occlusion of the sinoatrial node artery can be a complication of percutaneous intervention (PCI) to the right coronary artery (RCA). When this happens, dysfunction of the sinus node may follow resulting in sinus arrest.
Ebubechukwu Ezeh MD, Esiemoghie Akhigbe MD, Mohammad Amro MD, Ebad Ur Rahman MD, Saad Malik MD, Kanaan Mansoor MD, Mehiar Elhamdani MD   +6 more
doaj   +1 more source

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

Frontiers in Physiology, 2015
The heart’s regular electrical activity is initiated by specialized cardiac pacemaker cells residing in the sinoatrial node. The rate and rhythm of spontaneous action potential firing of sinoatrial node cells are regulated by stochastic mechanisms that ...
Yael eYaniv, Kenta eTsutsui, Edward eLakatta   +2 more
doaj   +1 more source