Results 31 to 40 of about 5,596 (157)

RyR2(R4496C) Expression Induces Sinoatrial Node Dysfunction [PDF]

Biophysical Journal, 2011
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is an arrhythmogenic disease characterized by stress-triggered syncope and sudden death. While ventricular tachycardia appears only during stress conditions, CPVT patients manifest basal sino-atrial node (SAN) dysfunction, but the underlying mechanism remains unknown.
Neco, Patricia, Torrente, Angelo, Zorio, Esther, Priori, Silvia G., Richard, Sylvain, Benitah, Jean-Pierre, Mangoni, Matteo, Gomez, Ana M.   +7 more
openaire   +2 more sources

Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice

JACC: Basic to Translational Science, 2018
Summary: Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the
Martin Mackasey, BSc, Emmanuel E. Egom, MD, PhD, Hailey J. Jansen, PhD, Rui Hua, PhD, Motahareh Moghtadaei, PhD, Yingjie Liu, PhD, Jaspreet Kaur, PhD, Megan D. McRae, BHSc, Oleg Bogachev, MD, Sara A. Rafferty, MSc, Gibanananda Ray, PhD, Adam W. Kirkby, MSc, Robert A. Rose, PhD   +12 more
doaj   +1 more source

A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia

Journal of Pharmacological Sciences, 2015
Although it has been reported that endotoxin-induced expression of Nox1 in the heart contributes to apoptosis in cardiomyocytes, functional role of Nox1 at the physiological expression level has not been elucidated.
Akiteru Kojima, Akio Matsumoto, Hirofumi Nishida, Yoshie Reien, Kazumi Iwata, Takeshi Shirayama, Chihiro Yabe-Nishimura, Haruaki Nakaya   +7 more
doaj   +1 more source

The Jailed Sinoatrial Node: An Interesting Case of Cardiogenic Shock Secondary to Sinus Arrest Following Percutaneous Intervention

Journal of Investigative Medicine High Impact Case Reports, 2022
Complete occlusion of the sinoatrial node artery can be a complication of percutaneous intervention (PCI) to the right coronary artery (RCA). When this happens, dysfunction of the sinus node may follow resulting in sinus arrest.
Ebubechukwu Ezeh MD, Esiemoghie Akhigbe MD, Mohammad Amro MD, Ebad Ur Rahman MD, Saad Malik MD, Kanaan Mansoor MD, Mehiar Elhamdani MD   +6 more
doaj   +1 more source

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

Frontiers in Physiology, 2015
The heart’s regular electrical activity is initiated by specialized cardiac pacemaker cells residing in the sinoatrial node. The rate and rhythm of spontaneous action potential firing of sinoatrial node cells are regulated by stochastic mechanisms that ...
Yael eYaniv, Kenta eTsutsui, Edward eLakatta   +2 more
doaj   +1 more source

The Involvement of TRPC3 channels in Sinoatrial Arrhythmias

Frontiers in Physiology, 2015
Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge.
Yue-Kun eJu, Bon Hyang Lee, Sofie eTrajanovska, Guoliang eHao, David G Allen, Ming eLei, Mark B Cannell   +6 more
doaj   +1 more source

Noninvasive Electrophysiological Research — Modern Method of Diagnostics of Heart Rhythm and Cardial Conduction Disorders in Children

Zdorovʹe Rebenka, 2012
In the article there are presented the data about history of development of noninvasive electrophysiological research and its application in pediatrics.
N.V. Nagornaya, Ye. V. Pshenichnaya, S.A. Parshin   +2 more
doaj   +1 more source

Trends in research on sick sinus syndrome: A bibliometric analysis from 2000 to 2022

Frontiers in Cardiovascular Medicine, 2022
Sick sinus syndrome (SSS) is a refractory arrhythmia disease caused by the pathological changes of sinoatrial node and its adjacent tissues. 2,251 publications related to SSS were retrieved from Web of Science database from 2000 to 2022 and analyzed by ...
Xin’ai Zhang, Yong Zhao, Yutong Zhou, Jiayu Lv, Jiaran Peng, Haiyan Zhu, Ruxiu Liu   +6 more
doaj   +1 more source

IVABRADINE IN PATIENTS WITH CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION: NEW DATA FROM THE SHIFT MULTICENTER RANDOMIZED TRIAL

Российский кардиологический журнал, 2016
Resting heart rate is a strong predictor of mortality and cardiovascular outcome in patients with chronic heart failure. А specific inhibitor of the If current in the sinoatrial node ivabradine improves clinical outcome in patients with heart failure and
S. N. Tereshchenko, I. V. Zirov, N. V. Romanova   +2 more
doaj   +1 more source

Mitochondrial dysfunction on sinoatrial node and pulmonary vein electrophysiological activities

Experimental and Therapeutic Medicine, 2017
Atrial fibrillation (AF) is associated with mitochondrial dysfunction. Sinoatrial node (SAN) dysfunction increases arrhythmogenesis of pulmonary veins (PVs), which is the most important trigger of AF; however, it is not clear whether mitochondrial dysfunction differentially regulates electrical activity of SANs and PVs.
Yung-Kuo, Lin, Chen-Chuan, Cheng, Min-Chien, Tsai, Pei-Yu, Wu, Yi-Ann, Chen, Yao-Chang, Chen, Shih-Ann, Chen, Yi-Jen, Chen   +7 more
openaire   +3 more sources