Genetic Complexity of Sinoatrial Node Dysfunction [PDF]
Frontiers in Genetics, 2021 The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace +16 more
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Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction [PDF]
Journal of Cardiovascular Development and Disease, 2022 Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022,
Weijie Chen +13 more
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Possible sinoatrial node dysfunction in a 6-month-old domestic shorthair cat [PDF]
Journal of Feline Medicine and Surgery Open ReportsCase summary A 6-month-old male entire domestic shorthair cat was presented to the ophthalmology department for nasolacrimal duct cannulation and flushing, and castration under general anaesthesia.
Florence Hillen, Laurent Locquet
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Pharmacologic Approach to Sinoatrial Node Dysfunction [PDF]
Annual Review of Pharmacology and Toxicology, 2021 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Pietro Mesirca +2 more
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Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation [PDF]
JCI Insight, 2022 Loss-of-function (LOF) variants in SCN1B, encoding the voltage-gated sodium channel β1/β1B subunits, are linked to neurological and cardiovascular diseases. Scn1b-null mice have spontaneous seizures and ventricular arrhythmias and die by approximately 21
Roberto Ramos-Mondragon +13 more
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Insulin mitigates acute ischemia–induced atrial fibrillation and sinoatrial node dysfunction ex vivo [PDF]
JCI InsightAcute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, mechanisms through which ischemia contributes to the development of POAF are not well understood.
Huiliang Qiu +5 more
doaj +4 more sources
Emerging Signaling Regulation of Sinoatrial Node Dysfunction [PDF]
Current Cardiology Reports, 2023 The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Mingjie Zheng, Shannon Erhardt, Jun Wang
exaly +4 more sources
Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction [PDF]
Circulation, 2022 Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits exercise capacity, a common problem in patients with heart failure with preserved ejection fraction
Thássio Ricardo Ribeiro Mesquita +2 more
exaly +6 more sources
Digenic heterozygous mutations of KCNH2 and SCN5A induced young and early‐onset long QT syndrome and sinoatrial node dysfunction [PDF]
Annals of Noninvasive Electrocardiology, 2022 Introduction Long QT syndrome (LQTS) is a life‐threatening inherited channelopathy, and prolonged QT intervals easily trigger malignant arrhythmias, especially torsades de pointes and ventricular fibrillation.
Zhe Yang +10 more
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Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report [PDF]
Frontiers in Cardiovascular MedicinePulmonary vein pulsed-field ablation (PFA) is widely regarded as a safe procedure for patients with atrial fibrillation (AF), with sinoatrial disturbances as a rare complication. A 62-year-old female patient with paroxysmal AF underwent ablation using an
Enyuan Zhang +8 more
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