Genetic Complexity of Sinoatrial Node Dysfunction [PDF]
Frontiers in Genetics, 2021 The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace +16 more
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Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report [PDF]
Frontiers in Cardiovascular MedicinePulmonary vein pulsed-field ablation (PFA) is widely regarded as a safe procedure for patients with atrial fibrillation (AF), with sinoatrial disturbances as a rare complication. A 62-year-old female patient with paroxysmal AF underwent ablation using an
Enyuan Zhang +8 more
doaj +6 more sources
Possible sinoatrial node dysfunction in a 6-month-old domestic shorthair cat [PDF]
Journal of Feline Medicine and Surgery Open ReportsCase summary A 6-month-old male entire domestic shorthair cat was presented to the ophthalmology department for nasolacrimal duct cannulation and flushing, and castration under general anaesthesia.
Florence Hillen, Laurent Locquet
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Pharmacologic Approach to Sinoatrial Node Dysfunction [PDF]
Annual Review of Pharmacology and Toxicology, 2021 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Isabelle Bidaud +2 more
exaly +7 more sources
Emerging Signaling Regulation of Sinoatrial Node Dysfunction [PDF]
Current Cardiology Reports, 2023 The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Jun Wang, Mingjie Zheng
exaly +6 more sources
Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction [PDF]
Journal of Cardiovascular Development and Disease, 2022 Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022,
Weijie Chen +13 more
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Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction [PDF]
Circulation, 2022 Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits exercise capacity, a common problem in patients with heart failure with preserved ejection fraction
Joshua I Goldhaber, Jae Hyung Cho
exaly +6 more sources
Function and Dysfunction of Human Sinoatrial Node [PDF]
Korean Circulation Journal, 2015 Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release). Using optical mapping in Langendorff-perfused canine right atrium, we previously demonstrated that the β-adrenergic stimulation pushes the ...
Joung, Boyoung, Chen, Peng-Sheng
core +7 more sources
Digenic heterozygous mutations of KCNH2 and SCN5A induced young and early‐onset long QT syndrome and sinoatrial node dysfunction [PDF]
Annals of Noninvasive Electrocardiology, 2022 Introduction Long QT syndrome (LQTS) is a life‐threatening inherited channelopathy, and prolonged QT intervals easily trigger malignant arrhythmias, especially torsades de pointes and ventricular fibrillation.
Zhe Yang +10 more
doaj +2 more sources
Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics. [PDF]
PLoS ONE, 2014 Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium.
Patric Glynn, Birce Onal, Thomas J Hund
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