Emerging Signaling Regulation of Sinoatrial Node Dysfunction [PDF]
Current Cardiology Reports, 2023 The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Mingjie Zheng +2 more
exaly +4 more sources
Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction [PDF]
Circulation, 2022 Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits exercise capacity, a common problem in patients with heart failure with preserved ejection fraction
Thassio Mesquita +2 more
exaly +6 more sources
CaMKII in sinoatrial node physiology and dysfunction
Frontiers in Pharmacology, 2014 The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu +2 more
doaj +3 more sources
Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction [PDF]
Frontiers in Physiology, 2015 Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of ...
Thomas A Csepe +4 more
doaj +3 more sources
Lithium-Induced Sinoatrial Node Dysfunction. [PDF]
Cureus, 2021 Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi A, Javed S, Paul T, Amor W.
europepmc +4 more sources
Sympatho-vagal balance and intrinsic sinoatrial node activity in larval zebrafish quantified by heart rate variability [PDF]
Scientific ReportsThe larval zebrafish is a powerful in vivo model for studying cardiac disease. Alterations in sympatho-vagal balance and intrinsic sinoatrial node activity, key contributors to cardiac dysfunction, can be assessed using heart rate variability (HRV ...
Layan Hamed +4 more
doaj +2 more sources
Sick Sinus Syndrome and Cerebral Venous Thrombosis: A Connection or Coincidence? A Case Report and Literature Review [PDF]
Oman Medical JournalIt has been hypothesized that increased intracranial pressure (ICP) may cause sick sinus syndrome (SSS) due to its effect on vagal discharge to the heart, resulting in disruption to the sinus cycle, despite age-related degeneration of the sinoatrial node
Alawi A. Al-Attas +5 more
doaj +2 more sources
D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism. [PDF]
Aging (Albany NY), 2023 With the population aging, age-related sinoatrial node dysfunction (SND) has been on the rise. Sinoatrial node (SAN) degeneration is an important factor for the age-related SND development. However, there is no suitable animal modeling method in this field.
Zhang H +13 more
europepmc +3 more sources
Medical Management of Hemodynamically Unstable Sinoatrial Node Dysfunction in a Patient With Intracardiac Lymphoma. [PDF]
JACC CardioOncol, 2021 [Figure: see text]
Martz CA +4 more
europepmc +3 more sources
Junctional Pacemaker May Replace the Sinoatrial Node
Cardiovascular Innovations and Applications, 2021 Junctional rhythm is usually seen in the clinic with different causes. We report a case of bicuspid aortic valve accompanied by sinoatrial node dysfunction.
Min Lin +4 more
doaj +1 more source