Function and dysfunction of human sinoatrial node [PDF]
Korean Circulation Journal, 2015 Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release).
Chen, Peng-Sheng, Joung, Boyoung
core +5 more sources
CaMKII in sinoatrial node physiology and dysfunction
Frontiers in Pharmacology, 2014 The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu +2 more
doaj +3 more sources
Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction [PDF]
Frontiers in Physiology, 2015 Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of ...
Thomas A Csepe +4 more
doaj +3 more sources
Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models [PDF]
Nature CommunicationsSinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu +9 more
doaj +2 more sources
Lithium-Induced Sinoatrial Node Dysfunction. [PDF]
Cureus, 2021 Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi A, Javed S, Paul T, Amor W.
europepmc +4 more sources
Sick Sinus Syndrome and Cerebral Venous Thrombosis: A Connection or Coincidence? A Case Report and Literature Review [PDF]
Oman Medical JournalIt has been hypothesized that increased intracranial pressure (ICP) may cause sick sinus syndrome (SSS) due to its effect on vagal discharge to the heart, resulting in disruption to the sinus cycle, despite age-related degeneration of the sinoatrial node
Alawi A. Al-Attas +5 more
doaj +2 more sources
D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism. [PDF]
Aging (Albany NY), 2023 With the population aging, age-related sinoatrial node dysfunction (SND) has been on the rise. Sinoatrial node (SAN) degeneration is an important factor for the age-related SND development. However, there is no suitable animal modeling method in this field.
Zhang H +13 more
europepmc +3 more sources
Medical Management of Hemodynamically Unstable Sinoatrial Node Dysfunction in a Patient With Intracardiac Lymphoma. [PDF]
JACC CardioOncol, 2021 [Figure: see text]
Martz CA +4 more
europepmc +3 more sources
Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice. [PDF]
J Gerontol A Biol Sci Med Sci, 2022 Abstract Heart rate (HR) is controlled by the sinoatrial node (SAN). SAN dysfunction is highly prevalent in aging; however, not all individuals age at the same rate. Rather, health status during aging is affected by frailty. Natriuretic peptides regulate SAN function in part by activating natriuretic peptide receptor C (NPR-C).
Jansen HJ +4 more
europepmc +3 more sources
Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice. [PDF]
Cardiovasc Diabetol, 2014 The aim of this study was to probe cardiac complications, including heart-rate control, in a mouse model of type-2 diabetes. Heart-rate development in diabetic patients is not straight forward: In general, patients with diabetes have faster heart rates compared to non-diabetic individuals, yet diabetic patients are frequently found among patients ...
Soltysinska E +3 more
europepmc +5 more sources