Results 21 to 30 of about 5,596 (157)
Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice. [PDF]
Cardiovasc Diabetol, 2014 The aim of this study was to probe cardiac complications, including heart-rate control, in a mouse model of type-2 diabetes. Heart-rate development in diabetic patients is not straight forward: In general, patients with diabetes have faster heart rates compared to non-diabetic individuals, yet diabetic patients are frequently found among patients ...
Soltysinska E +3 more
europepmc +5 more sources
Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics. [PDF]
PLoS ONE, 2014 Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium.
Patric Glynn, Birce Onal, Thomas J Hund
doaj +1 more source
Function and Dysfunction of Human Sinoatrial Node [PDF]
Korean Circulation Journal, 2015 Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release). Using optical mapping in Langendorff-perfused canine right atrium, we previously demonstrated that the β-adrenergic stimulation pushes the ...
Joung, Boyoung, Chen, Peng-Sheng
openaire +3 more sources
Pathophysiology of Cav1.3 L-type calcium channels in the heart
Frontiers in Physiology, 2023 Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri +10 more
doaj +1 more source
The role of the calcium and the voltage clocks in sinoatrial node dysfunction. [PDF]
Yonsei Med J, 2011 Recent evidence indicates that the voltage clock (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release) jointly regulate sinoatrial node (SAN) automaticity. However, the relative importance of the voltage clock and Ca(2+) clock for pacemaking was not revealed in sick ...
Joung B, Chen PS, Lin SF.
europepmc +4 more sources
A Case of Complete AV Blockade in Patient with Lyme Borreliosis
Архивъ внутренней медицины, 2022 Lyme disease (tick-borne borreliosis) is an infectious vector-borne natural focal disease that tends to a chronic and recurrent course with a predominant damage to the skin, nervous system, musculoskeletal system and heart. Cardiac features is manifested,
O. N. Denisov +2 more
doaj +1 more source
The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction [PDF]
Journal of Interventional Cardiac Electrophysiology, 2015 The sinoatrial node (SAN) and the atrioventricular node (AVN) are the anatomical and functional regions of the heart which play critical roles in the generation and conduction of the electrical impulse. Their functions are ensured by peculiar structural cytological properties and specific collections of ion channels.
R. Milanesi, A. Bucchi, M. Baruscotti
openaire +2 more sources
Staged operation to fontan increases the incidence of sinoatrial node dysfunction [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 1996 Morbidity and mortality of total cavopulmonary connection (modified Fontan procedure) may be decreased in many patients with single ventricle in whom the risk of surgery is high by performing the operations in a staged fashion. Each operative intervention, however, exposes the sinoatrial node region to risk of injury, and a multistaged approach may ...
Manning, Peter B. +4 more
openaire +2 more sources
Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats. [PDF]
PLoS ONE, 2013 In the last ten years, the incidences of metabolic syndrome and supraventricular arrhythmias have greatly increased. The metabolic syndrome is a cluster of alterations, which include obesity, hypertension, hypertriglyceridemia, glucose intolerance and ...
Alondra Albarado-Ibañez +4 more
doaj +1 more source
Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundTwo‐pore K+ channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K ...
Sathya D. Unudurthi +13 more
doaj +1 more source