Results 21 to 30 of about 975,812 (179)

CaMKII in sinoatrial node physiology and dysfunction

Frontiers in Pharmacology, 2014
The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu, Mark E Anderson, Mark E Anderson   +2 more
doaj   +3 more sources

Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice. [PDF]

Cardiovasc Diabetol, 2014
The aim of this study was to probe cardiac complications, including heart-rate control, in a mouse model of type-2 diabetes. Heart-rate development in diabetic patients is not straight forward: In general, patients with diabetes have faster heart rates compared to non-diabetic individuals, yet diabetic patients are frequently found among patients ...
Soltysinska E, Speerschneider T, Winther SV, Thomsen MB.   +3 more
europepmc   +7 more sources

Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation [PDF]

JCI Insight, 2022
Loss-of-function (LOF) variants in SCN1B, encoding the voltage-gated sodium channel β1/β1B subunits, are linked to neurological and cardiovascular diseases. Scn1b-null mice have spontaneous seizures and ventricular arrhythmias and die by approximately 21
Roberto Ramos-Mondragon, Nnamdi Edokobi, Samantha L. Hodges, Shuyun Wang, Alexandra A. Bouza, Chandrika Canugovi, Caroline Scheuing, Lena Juratli, William R. Abel, Sami F. Noujaim, Nageswara R. Madamanchi, Marschall S. Runge, Luis F. Lopez-Santiago, Lori L. Isom   +13 more
doaj   +2 more sources

Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction [PDF]

Frontiers in Physiology, 2015
Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of ...
Thomas A Csepe, Anuradha eKalyanasundaram, Brian J Hansen, Jichao eZhao, Vadim V Fedorov   +4 more
doaj   +3 more sources

Staged operation to fontan increases the incidence of sinoatrial node dysfunction [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1996
Morbidity and mortality of total cavopulmonary connection (modified Fontan procedure) may be decreased in many patients with single ventricle in whom the risk of surgery is high by performing the operations in a staged fashion. Each operative intervention, however, exposes the sinoatrial node region to risk of injury, and a multistaged approach may ...
Manning, Peter B., Mayer, John E., Wernovsky, Gil, Fishberger, Steven B., Walsh, Edward P.   +4 more
openaire   +4 more sources

Insulin mitigates acute ischemia–induced atrial fibrillation and sinoatrial node dysfunction ex vivo [PDF]

JCI Insight
Acute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, mechanisms through which ischemia contributes to the development of POAF are not well understood.
Huiliang Qiu, Fan Li, Hannah Prachyl, Alejandra Patino-Guerrero, Michael Rubart, Wuqiang Zhu   +5 more
doaj   +2 more sources

Use of machine learning and Poincaré density grid in the diagnosis of sinus node dysfunction caused by sinoatrial conduction block in dogs

Journal of Veterinary Internal Medicine
Background Sinus node dysfunction because of abnormal impulse generation or sinoatrial conduction block causes bradycardia that can be difficult to differentiate from high parasympathetic/low sympathetic modulation (HP/LSM).
Wyatt Hutson Flanders, N. Sydney Moïse, Niels F. Otani   +2 more
doaj   +2 more sources

The sophisticated architecture of the rat atrioventricular node [PDF]

, 2005
In the mammalian heart, the action potential spontaneously generated in the sinoatrial (SA) node propagates through the atria to reach the atrioventricular (AV) node.
Yoo, Shin
core   +9 more sources

Lithium-Induced Sinoatrial Node Dysfunction. [PDF]

Cureus, 2021
Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi A, Javed S, Paul T, Amor W.
europepmc   +4 more sources

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction [PDF]

Journal of Interventional Cardiac Electrophysiology, 2015
The sinoatrial node (SAN) and the atrioventricular node (AVN) are the anatomical and functional regions of the heart which play critical roles in the generation and conduction of the electrical impulse. Their functions are ensured by peculiar structural cytological properties and specific collections of ion channels.
R. Milanesi, A. Bucchi, M. Baruscotti
openaire   +4 more sources