Results 1 to 10 of about 972,180 (179)

Emerging Signaling Regulation of Sinoatrial Node Dysfunction [PDF]

Current Cardiology Reports, 2023
The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Jun Wang, Mingjie Zheng, Shannon Erhardt   +2 more
exaly   +6 more sources

Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction [PDF]

Circulation, 2022
Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits exercise capacity, a common problem in patients with heart failure with preserved ejection fraction
Joshua Goldhaber, Jae Hyung Cho
exaly   +6 more sources

Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics. [PDF]

PLoS ONE, 2014
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium.
Patric Glynn, Birce Onal, Thomas J Hund
doaj   +2 more sources

Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models [PDF]

Nature Communications
Sinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu, Yangxi Zeng, Wei Fan, Xi Lan, Can Liu, Yisong He, Zhaoting Li, Kewei Jia, Juyi Wan, Bin Liao   +9 more
doaj   +2 more sources

Sinus arrest in a patient with acute coronary syndrome due to a rare anatomical variation in the sinoatrial nodal artery [PDF]

BMC Cardiovascular Disorders
Background Sinus node dysfunction can occur in patients with acute coronary syndrome (ACS), particularly in inferior myocardial infarction. Because the sinoatrial nodal artery (SANa) shows considerable anatomical variation, ischemia-related sinus arrest ...
Yoshiyasu Aizawa, Akihiro Yoshizawa, Tomoko S. Kato, Akio Kawamura   +3 more
doaj   +2 more sources

Sympatho-vagal balance and intrinsic sinoatrial node activity in larval zebrafish quantified by heart rate variability [PDF]

Scientific Reports
The larval zebrafish is a powerful in vivo model for studying cardiac disease. Alterations in sympatho-vagal balance and intrinsic sinoatrial node activity, key contributors to cardiac dysfunction, can be assessed using heart rate variability (HRV ...
Layan Hamed, Nir Almog, Inbar Brosh, Yael Yaniv, Limor Freifeld   +4 more
doaj   +2 more sources

Junctional Pacemaker May Replace the Sinoatrial Node

Cardiovascular Innovations and Applications, 2021
Junctional rhythm is usually seen in the clinic with different causes. We report a case of bicuspid aortic valve accompanied by sinoatrial node dysfunction.
Min Lin, Yuqin Xiong, Yipin Lin, Yuhua Li, Lijuan Zhang   +4 more
doaj   +1 more source

Pathophysiology of Cav1.3 L-type calcium channels in the heart

Frontiers in Physiology, 2023
Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri, Sahil Zaveri, Ujala Srivastava, Yongxia Sarah Qu, Yongxia Sarah Qu, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Chahine, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir   +10 more
doaj   +1 more source

A Case of Complete AV Blockade in Patient with Lyme Borreliosis

Архивъ внутренней медицины, 2022
Lyme disease (tick-borne borreliosis) is an infectious vector-borne natural focal disease that tends to a chronic and recurrent course with a predominant damage to the skin, nervous system, musculoskeletal system and heart. Cardiac features is manifested,
O. N. Denisov, E. V. Efremova, A. A. Nafeev   +2 more
doaj   +1 more source

Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats. [PDF]

PLoS ONE, 2013
In the last ten years, the incidences of metabolic syndrome and supraventricular arrhythmias have greatly increased. The metabolic syndrome is a cluster of alterations, which include obesity, hypertension, hypertriglyceridemia, glucose intolerance and ...
Alondra Albarado-Ibañez, José Everardo Avelino-Cruz, Myrian Velasco, Julián Torres-Jácome, Marcia Hiriart   +4 more
doaj   +1 more source