Genetic Complexity of Sinoatrial Node Dysfunction [PDF]
Frontiers in Genetics, 2021 The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J Wallace +2 more
exaly +7 more sources
Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction [PDF]
Journal of Cardiovascular Development and Disease, 2022 Cardioneuroablation (CNA) is proposed as a promising therapy for patients with sinoatrial node dysfunction (SND) that is mediated by excessive vagal tone. However, a series of urgent questions about CNA remain unanswered. From December 2020 to March 2022,
Peilin Xiao, Fang Qin, Xianbin Lan
exaly +4 more sources
Pharmacologic Approach to Sinoatrial Node Dysfunction [PDF]
Annual Review of Pharmacology and Toxicology, 2021 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Pietro Mesirca +2 more
exaly +6 more sources
Possible sinoatrial node dysfunction in a 6-month-old domestic shorthair cat [PDF]
Journal of Feline Medicine and Surgery Open ReportsCase summary A 6-month-old male entire domestic shorthair cat was presented to the ophthalmology department for nasolacrimal duct cannulation and flushing, and castration under general anaesthesia.
Florence Hillen, Laurent Locquet
doaj +4 more sources
Digenic heterozygous mutations of KCNH2 and SCN5A induced young and early‐onset long QT syndrome and sinoatrial node dysfunction [PDF]
Annals of Noninvasive Electrocardiology, 2022 Introduction Long QT syndrome (LQTS) is a life‐threatening inherited channelopathy, and prolonged QT intervals easily trigger malignant arrhythmias, especially torsades de pointes and ventricular fibrillation.
Zhe Yang +10 more
doaj +2 more sources
Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report [PDF]
Frontiers in Cardiovascular MedicinePulmonary vein pulsed-field ablation (PFA) is widely regarded as a safe procedure for patients with atrial fibrillation (AF), with sinoatrial disturbances as a rare complication. A 62-year-old female patient with paroxysmal AF underwent ablation using an
Enyuan Zhang +8 more
doaj +2 more sources
Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation [PDF]
JCI Insight, 2022 Loss-of-function (LOF) variants in SCN1B, encoding the voltage-gated sodium channel β1/β1B subunits, are linked to neurological and cardiovascular diseases. Scn1b-null mice have spontaneous seizures and ventricular arrhythmias and die by approximately 21
Roberto Ramos-Mondragon +13 more
doaj +2 more sources
Insulin mitigates acute ischemia–induced atrial fibrillation and sinoatrial node dysfunction ex vivo [PDF]
JCI InsightAcute atrial ischemia is a well-known cause of postoperative atrial fibrillation (POAF). However, mechanisms through which ischemia contributes to the development of POAF are not well understood.
Huiliang Qiu +5 more
doaj +2 more sources
Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity. [PDF]
J PhysiolAbstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
MacDonald EA, Quinn TA.
europepmc +2 more sources
Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models [PDF]
Nature CommunicationsSinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu +9 more
doaj +2 more sources