Results 61 to 70 of about 10,507 (197)

The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation [PDF]

, 2013
Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein–activated K+ current (IKACh) in the control of SAN pacemaking and heart rate is not ...
Audoubert, Matthieu, Clapham, David E., Couette, Brigitte, DiFrancesco, Mattia L., Dubel, Stefan, Leoni, Anne-Laure, Mangoni, Matteo E., Marger, Laurine, Mesirca, Pietro, Muller, Jana Christina, Nargeot, Joël, Rizzetto, Riccardo, Torrente, Angelo G., Toyoda, Futoshi, Wickman, Kevin   +14 more
core   +3 more sources

Molecular and Electrophysiological Mechanisms Underlying Cardiac Arrhythmogenesis in Diabetes Mellitus. [PDF]

, 2016
This is the final version of the article. It first appeared from Hindawi via https://doi.org/10.1155/2016/2848759Diabetes is a common endocrine disorder with an ever increasing prevalence globally, placing significant burdens on our healthcare systems ...
Lai, Eric Tsz Him, Tse, Gary, Tse, Vivian, Yeo, Jie Ming   +3 more
core   +3 more sources

Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models

Pediatric Discovery, EarlyView.
ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou, Christopher L.‐H. Huang, Ying Yang, Yanmin Zhang   +3 more
wiley   +1 more source

Rare Case of Rapidly Worsening REM Sleep Induced Bradycardia

Case Reports in Cardiology, 2015
Sinoatrial arrest also known as sinus pause occurs when sinoatrial node of the heart transiently ceases to generate the electrical impulse necessary for the myocardium to contract. It may last from 2.0 seconds to several minutes. Etiologies of sinoatrial
Ayyappa S. Duba, Suneetha Jasty, Ankit Mahajan, Vijay Kodadhala, Raza Khan, Prithviraj Rai, Mohammad Ghazvini   +6 more
doaj   +1 more source

The Role of Ivabradine in the Management of Angina Pectoris [PDF]

, 2016
Stable angina pectoris affects 2–4 % of the population in Western countries and entails an annual risk of death and nonfatal myocardial infarction of 1–2 % and 3 %, respectively.
De Silva, R, Giavarini, A
core   +2 more sources

Werner Irnich: Pioneer in the Development of the Dual‐Chamber Pacemaker—An Obituary

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Fifty years ago, Werner Irnich presented the concept of an optimal pacemaker capable of responding appropriately to various cardiac arrhythmias and perceptual disturbances, and intended to be used in 85% of patients. With this concept, Irnich was far ahead of his time. His proposed circuitry for AV block and atrial fibrillation, as well as his
Bernd Lemke
wiley   +1 more source

Use of machine learning and Poincaré density grid in the diagnosis of sinus node dysfunction caused by sinoatrial conduction block in dogs

Journal of Veterinary Internal Medicine
Background Sinus node dysfunction because of abnormal impulse generation or sinoatrial conduction block causes bradycardia that can be difficult to differentiate from high parasympathetic/low sympathetic modulation (HP/LSM).
Wyatt Hutson Flanders, N. Sydney Moïse, Niels F. Otani   +2 more
doaj   +1 more source

The Evolution of Sinoatrial Node Function in Man [PDF]

, 1973
The function of the sinoatrial node is complex. In nearly all hearts, this small bit of tissue is responsible for spontaneously generating the impulse which will be distributed to the remainder of the heart, maintaining coordinated electrical and ...
Bigger, J. Thomas, Strauss, Harold C.
core   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Heart Rate Reserve in Fontan Patients: Chronotropic Incompetence or Hemodynamic Limitation?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Patients with a Fontan circulation achieve lower peak heart rates (HR) during exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial node or is a consequence of altered cardiac hemodynamics is uncertain.
Guido Claessen, Andre La Gerche, Alexander Van De Bruaene, Mathias Claeys, Rik Willems, Steven Dymarkowski, Jan Bogaert, Piet Claus, Werner Budts, Hein Heidbuchel, Marc Gewillig   +10 more
doaj   +1 more source