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Aging and Sinoatrial Node Dysfunction [PDF]
In the century since the discovery by Keith and Flack of the sinoatrial node in the mole heart, a detailed mosaic of its cellular, anatomic, and electrophysiological properties has emerged. The human sinus node has been found to be anatomically constant and well localized, occupying an approximately 10-mm subepicardial region on the sulcus terminalis ...
Haris M Haqqani
exaly +2 more sources
Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation [PDF]
The mechanism of sinoatrial node (SAN) dysfunction in atrial fibrillation (AF) is unclear.The purpose of this study was to test the hypothesis that defective spontaneous sarcoplasmic reticulum (SR) Ca(2+) release (Ca(2+) clock) is in part responsible for SAN dysfunction in AF.Arrhythmic events and SAN function were evaluated in pacing-induced AF dogs ...
Shien-Fong Lin +2 more
exaly +5 more sources
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Heat Stroke–Induced Sinoatrial Node Dysfunction
Journal of Emergency Medicine, 2015Heat stroke has been associated with stress-induced cardiomyopathy and electrocardiogram ST segment elevation and depression. Laboratory studies with dogs have demonstrated heat stroke-induced sinoatrial node dysfunction in the setting of hyperkalemia.
Daniel, Case, Richard, Harrigan
exaly +3 more sources
Changes in Ion Channel Gene Expression Underlying Heart Failure-Induced Sinoatrial Node Dysfunction [PDF]
Background— Heart failure (HF) causes a decline in the function of the pacemaker of the heart—the sinoatrial node (SAN). The aim of the study was to investigate HF-induced changes in the expression of the ion channels and related proteins underlying the pacemaker activity of the SAN.
Joseph Yanni +2 more
exaly +3 more sources
A low dose of amiodarone-indused sinoatrial node dysfunction: a case report
CARDIOMETRY, 2022We recently treated a case similar to that reported by Mun et al and Chinushi M. Holter ECG demonstrated paroxysmal atrial fibrillation, frequent ventricular ectopy’s, atrial tachycardia. The patient complained of palpitation. We have prescribed and amiodarone (100 mg/day) per day for 2 months. In the second visit, the palpitation attacks were relieved.
D. Amgalanbaatar +4 more
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The Sinoatrial Node and Its Dysfunction
1987The purpose of this chapter is to review the function and dysfunction of the sinoatrial node (SAN). The majority of the chapter encompasses SAN dysfunction: surface electrocardiography; clinical manifestations; noninvasive evaluation; intracardiac electrophysiology and treatment.
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Sinoatrial node dysfunction after stereotactic ablative radiation therapy in the chest.
Journal of Clinical Oncology, 2017132 Background: Sinoatrial node (SAN) injury following stereotactic ablative radiation therapy (SABR) in the chest has not been reported in the literature. We report SAN dysfunction as a potential toxicity of SABR in the chest. Methods: We examined the clinical courses and SABR plans of 47 patients treated for T1 or T2 non-small cell lung cancer of ...
Yushen Qian +14 more
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[Non-invasive tests in the diagnosis of sinoatrial node dysfunction].
Vnitrni lekarstvi, 1994The authors present a group of 67 patients, mean age 63 +/- 15 years, where they applied on account of suspected dysfunction of the sinoatrial node (SA) the atropine test (AT), 24-hour Holter monitoring and transoesophageal stimulation of the atria (TESP). The objective of the investigation was to test the reliability and yield of the mentioned methods
B, Stancák +5 more
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[Diagnosis and treatment of sinoatrial node dysfunction].
Klinicheskaia meditsina, 2003Sick sinus syndrome is characterized by disturbance of its automatic function and (or) sinu-atrial conductivity caused by organic or vegetative defects. Diagnostic algorithm includes: clinical evidence, ECG, Holter monitoring, electrophysiological investigation, pharmacological test. Treatment is pharmacological and surgical.
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