Results 91 to 100 of about 142,538 (247)

Concurrent Use of Tasipimidine Oral Solution and Fluoxetine in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This exploratory randomized crossover study investigated pharmacokinetic interactions, functional alertness, and cardiovascular safety of tasipimidine oral solution administered alone and in combination with fluoxetine in healthy Beagle dogs (n = 8; 4 dogs per dose level), with a 7‐day washout between phases. Dogs received single oral doses of
Jenni Lindstedt, Jouko M. Levijoki, Johanna Tuunainen, Jens Häggström, Meri Ramela, Mira Korpivaara   +5 more
wiley   +1 more source

CAROTID ARTERY STENTING IN A PATIENT WITH SINUS BRADYCARDIA: CLINICAL CASE [PDF]

, 2018
Syndrome of hemodynamic depression is a frequent complication of the carotid artery endovascular intervention and, as a rule, is transient in nature. This article presents a clinical case of carotid artery stenting in a 63-year-old patient.
B. A. Rudenko, E. S. Bulgakova, T. V. Tvorogova, O. M. Drapkina   +3 more
core   +1 more source

Werner Irnich: Pioneer in the Development of the Dual‐Chamber Pacemaker—An Obituary

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Fifty years ago, Werner Irnich presented the concept of an optimal pacemaker capable of responding appropriately to various cardiac arrhythmias and perceptual disturbances, and intended to be used in 85% of patients. With this concept, Irnich was far ahead of his time. His proposed circuitry for AV block and atrial fibrillation, as well as his
Bernd Lemke
wiley   +1 more source

Juvenile dermatomyositis with a rare and remarkable complication: sinus bradycardia

, 2006
Juvenile dermatomyositis (JDM) is characterized by proximal muscle weakness, vasculopathy of the skin and muscles, and typical skin rash. Approximately, 70% of adult patients with dermatomyositis have evidence of cardiac damage.
Kutukculer, Necil, Yeniay, Betul Sozeri, Karaca, Neslihan Edeer, Aksu, Guzide   +3 more
core   +1 more source

Reflex Syncope With Complete Heart Block Triggered by Swallowing in a Patient on Immune Checkpoint Inhibitor Therapy

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) are now standard of care for most advanced solid tumors. While effective, they are associated with immune‐related adverse events (irAEs), including rare autonomic complications. We present a patient with metastatic lung adenocarcinoma receiving nivolumab and ipilimumab who developed reflex syncope with ...
Ashley Bouzon, Michael Oropesa, Bardia Adibmoradi, Daniel Weitz   +3 more
wiley   +1 more source

Electrophysiological and sick sinus syndrome effects of Remdesivir challenge in guinea-pig hearts

Frontiers in Physiology
Remdesivir (RDV) is the first drug approved by the FDA for clinical treatment of hospitalized patients infected with COVID-19 because it has been shown to have good antiviral activity against a variety of viruses, including Arenaviridae and Coronaviridae
Shuang Li, Liang Yue, Yulong Xie, Henggui Zhang, Henggui Zhang, Henggui Zhang   +5 more
doaj   +1 more source

Heart rate changes during partial seizures: A study amongst Singaporean patients

BMC Neurology, 2001
Introduction Studies in Europe and America showed that tachycardia, less often bradycardia, frequently accompanied partial seizures in Caucasian patients.
Lim Shih-Hui, Wilder-Smith Einar
doaj   +1 more source

Internal Jugular Vein as an Alternative Access for Pacemaker Implantation: A Mostly Left IJ Case Series

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Leadless pacemakers traditionally rely on femoral venous access, which may be limited in patients with unfavorable IVC anatomy, prior interventions, or situations where preserving femoral access is preferred. Internal jugular (IJ) access offers an alternative route, but real‐world data on IJ implantation of single‐ and dual‐chamber ...
Maya Asami Takagi, William Leon, Colin Mackenzie, Daniel Cortez   +3 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

Asymptomatic Profound Sinus Bradycardia (Heart Rate ≤45) in Non-small Cell Lung Cancer Patients Treated with Crizotinib [PDF]

, 2011
:Crizotinib, a dual MET/ALK inhibitor, is now in advanced clinical development for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC).
Joni Dy, Jonathan A. Stiber, Stiber, Jonathan A., Ou, Sai-Hong Ignatius, Dy, Joni, Azada, Michele, Sai-Hong Ignatius Ou, Michele Azada   +7 more
core   +1 more source