Results 81 to 90 of about 142,538 (247)

A randomized phase 2 trial of socrodeucitinib in moderate‐to‐severe plaque psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In moderate‐to‐severe plaque psoriasis, socrodeucitinib (6 mg/12 mg) significantly outperformed placebo at week 12: PASI 75 response rates 28.6%/72.1% vs. 7.5%. Meanwhile, socrodeucitinib illustrated a favourable safety and tolerability profile, warranting further study.
Ling Han, Songmei Geng, Yangfeng Ding, Shifa Zhang, Xiaohua Wang, Fengming Hu, Jianguo Li, Chao Ci, Yayu Hu, Rixin Chen, Jianping Zhang, Xiaoyong Zhou, Aijun Chen, Chunlei Zhang, Tiechi Lei, Yanyan Feng, Yu Wang, Zudong Meng, Yan Zhou, Mingkai Ji, Wei Liu, Yunting Wu, Qianying Chen, Siyi Wang, Jinhua Xu   +24 more
wiley   +1 more source

A curious alliance: Sinus nodal dysfunction precipitating atrioventricular block

Journal of Arrhythmia, 2014
An elderly woman presented with recurrent syncope. Sinus bradycardia and sinoatrial block were seen on the electrocardiogram; however, PR interval prolongation after sinus pauses suggested atrioventricular conduction system disease.
Sreekanth Yerram, MD, Chandramohan Ramasamy, MD, Jayaraman Balachander, MD, DM, Raja J. Selvaraj, MD, DNB   +3 more
doaj   +1 more source

Rosmarinus officinalis essential oil components promote anaesthesia in Colossoma macropomum (Cuvier, 1818) through behavioural and cardiorespiratory modulation

Journal of Fish Biology, EarlyView.
Abstract Anaesthetic management plays a crucial role in maintaining the welfare and physiological stability of fish during routine aquaculture and research procedures. The essential oil of Rosmarinus officinalis (ROEO) has emerged as a promising natural anaesthetic; however, its cardiophysiological effects in Amazonian species remain underexplored ...
Lorena Cristina Nunes de Almeida, Axell Lins, Daniella Bastos de Araújo, Maria Klara Otake Hamoy, Marcelo Victor dos Santos Brito, Luana Vasconcelos de Souza, Sarah Farias Câmara, Luciana Eiro Quirino, Nilton Akio Muto, Moisés Hamoy   +9 more
wiley   +1 more source

Hypothyroidism and sinus dysfunction associated with lithium-paliperidone combination therapy for bipolar disorder with psychotic symptoms: a case report

Frontiers in Psychiatry
Background and aimLithium is considered to be the first-line treatment for bipolar disorder, and paliperidone was approved for the treatment of schizophrenia and acute bipolar manic/mixed episodes.
Wenjian Wei, Yonglan Yang, Haifeng Wang, Yunbin Yang, Jizhou Liu, Jizhou Liu, Jinfeng Li   +6 more
doaj   +1 more source

Identification and Treatment of Anorexia Nervosa in Women With Perimenopause

Journal of Midwifery &Women's Health, EarlyView.
Abstract Disordered eating is a common problem that midwives will encounter as frontline primary care providers. Anorexia nervosa (AN) is a form of disordered eating that results in chronic starvation state, creating significant risk of morbidity and mortality to the patient. AN is traditionally considered a disorder of adolescence and young adulthood;
Janell Senda, Sarah Carpenter, Mary Carter‐Orbke   +2 more
wiley   +1 more source

Data_Sheet_1_Long QT Syndrome and Sinus Bradycardia–A Mini Review.PDF

, 2018
Congenital long-QT syndrome (LQTS) is an inherited cardiac disorder characterized by the prolongation of ventricular repolarization, susceptibility to Torsades de Pointes (TdP), and a risk for sudden death. Various types of congenital LQTS exist, all due
Ronald Wilders (358062), Arie O. Verkerk (127718)   +1 more
core   +1 more source

Mechanism of Sinus Bradycardia in Carriers of the A414G Mutation in the HCN4 Gene [PDF]

, 2019
Heterozygous carriers of the A414G mutation in the HCN4 gene, which encodes the HCN4 protein, show moderate to severe sinus bradycardia. Tetramers of HCN4 subunits constitute the ion channels that conduct the cardiac hyperpolarization-activated 'funny ...
Wilders, Ronald, Verkerk, Arie O.
core   +1 more source

Profile of Neonates Admitted With Hypoxic‐Ischemic Encephalopathy and Early Neurodevelopment Outcomes: A Retrospective Cohort Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Objective To evaluate contemporary clinical profiles and early neurodevelopmental outcomes of neonates admitted with hypoxic–ischemic encephalopathy (HIE) in an Australian tertiary perinatal unit. Study Design A retrospective cohort study (2019–2025) of neonates born ≥ 35 weeks' gestation admitted with a diagnosis of HIE.
Visothpong Chhoam, Nicole Ng, Abdul Razak, Vathana Sackett, Annie Bourke, Pramod Pharande, Rod W. Hunt, Lindsay Zhou, Atul Malhotra   +8 more
wiley   +1 more source

Accuracy and agreement of a wearable device for heart rate and oxygen saturation monitoring in awake dogs

Journal of Small Animal Practice, EarlyView.
Objectives The present study evaluated the accuracy and agreement of heart rate and peripheral oxygen saturation measurements obtained using the Owlet Smart Sock in awake dogs with low activity levels, using a veterinary patient monitor as the reference method.
Ş. Melek, Ö. T. Orhun, M. G. Şenocak, T. Arslan   +3 more
wiley   +1 more source

A perspective on automated rapid eye movement sleep assessment

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Rapid eye movement sleep is associated with distinct changes in various biomedical signals that can be easily captured during sleep, lending themselves to automated sleep staging using machine learning systems. Here, we provide a perspective on the critical characteristics of biomedical signals associated with rapid eye movement sleep and how ...
Mathias Baumert, Huy Phan
wiley   +1 more source