Results 101 to 110 of about 41,287 (294)

Delayed cardiac consequences unveiled by magnetic resonance imaging in a high‐voltage electric shock survivor

ESC Heart Failure, Volume 12, Issue 3, Page 2377-2381, June 2025.
Golnaz Houshmand, Majid Sadeghpour, Faezeh Tabesh   +2 more
wiley   +1 more source

A Phase I, First‐In‐Human Study of CBA‐1205, an Anti‐DLK1 Monoclonal Antibody, in Patients With Advanced Solid Tumors

Cancer Science, Volume 116, Issue 4, Page 1012-1022, April 2025.
We conducted a Phase I trial of CBA‐1205, a novel monoclonal antibody targeting DLK1, in advanced solid tumors, demonstrating safety and tolerability with no dose‐limiting toxicities. Preliminary efficacy was observed, with six patients achieving stable disease for over 6 months, and sDLK1 was identified as a potential biomarker associated with ...
Yuki Katsuya, Masafumi Ikeda, Takafumi Koyama, Jun Sato, Mao Okada, Nobuaki Matsubara, Chihiro Kondoh, Toru Mukohara, Kazuo Watanabe, Daisuke Kotani, Yoshimi Ogawa, Shose Taoka, Noboru Yamamoto   +12 more
wiley   +1 more source

Hypothyroidism and sinus dysfunction associated with lithium-paliperidone combination therapy for bipolar disorder with psychotic symptoms: a case report

Frontiers in Psychiatry
Background and aimLithium is considered to be the first-line treatment for bipolar disorder, and paliperidone was approved for the treatment of schizophrenia and acute bipolar manic/mixed episodes.
Wenjian Wei, Yonglan Yang, Haifeng Wang, Yunbin Yang, Jizhou Liu, Jizhou Liu, Jinfeng Li   +6 more
doaj   +1 more source

Large Neural Network Based Detection of Apnea, Bradycardia and Desaturation Events [PDF]

Neural Information Processing Systems (NIPS) 2017 Workshop on Machine Learning for Health, Long Beach, CA, USA, 2017
Apnea, bradycardia and desaturation (ABD) events often precede life-threatening events including sepsis in newborn babies. Here, we explore machine learning for detection of ABD events as a binary classification problem. We investigate the use of a large neural network to achieve a good detection performance.
arxiv  

Transient unexpected improvement of AV conduction: What is the mechanism? [PDF]

, 2006
This ECG was recorded from a 93 year old patient with a previously documented third degree AV block and an underlying LBBB. The twelve lead ECG demonstrates sinus bradycardia at a rate of 52 beats per minute, a PR interval of 230 milliseconds, and a ...
Friedman, Meir, Schweitzer, Paul
core   +2 more sources

Safety and effectiveness of fingolimod in Japanese patients with multiple sclerosis: Results of a post‐marketing surveillance study

Clinical and Experimental Neuroimmunology, Volume 16, Issue 2, Page 118-131, May 2025.
Abstract Objective Fingolimod is the first oral sphingosine‐1‐phosphate receptor modulator approved in Japan for multiple sclerosis (MS). A large Japanese observational study of fingolimod in patients with MS was carried out to support its safety and effectiveness in a real‐world setting.
Noriko Sato, Koji Wakimoto, Kyoko Kato, Yutaka Susuta, Kengo Ueda, Yoshihisa Satou, Takayoshi Sasajima, Jun‐ichi Kira   +7 more
wiley   +1 more source

Isolated Fetal Sinus Bradycardia as a First Sign of Congenital HypopituitarismNovel Teaching Points

CJC Open, 2020
We present a case of marked fetal sinus bradycardia as the sole presenting sign of congenital combined pituitary hormone deficiencies. Fetal sinus bradycardia < 120 beats/min was detected at 36 weeks of gestation during an otherwise uncomplicated ...
Simon Lapointe, MD, Diane Rottembourg, MD, Frederic Dallaire, MD, PhD   +2 more
doaj  

Atrial Fibrillation (AF) and Heart Failure With Preserved Ejection Fraction (HFpEF): Advances and Challenges

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT This state‐of‐the‐art review is based on the Philippe Coumel Lecture in 2024 (Figure 1). It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heart failure, with preserved ejection fraction. In these conditions, advances in electrophysiology and heart failure physiology are intertwined and are integrated ...
Sanjeev Saksena, April Slee, Ranghadham Nagarakanti, Atul Prakash   +3 more
wiley   +1 more source

A curious alliance: Sinus nodal dysfunction precipitating atrioventricular block

Journal of Arrhythmia, 2014
An elderly woman presented with recurrent syncope. Sinus bradycardia and sinoatrial block were seen on the electrocardiogram; however, PR interval prolongation after sinus pauses suggested atrioventricular conduction system disease.
Sreekanth Yerram, MD, Chandramohan Ramasamy, MD, Jayaraman Balachander, MD, DM, Raja J. Selvaraj, MD, DNB   +3 more
doaj   +1 more source

Prohormones in the early diagnosis of cardiac syncope [PDF]

, 2017
Background--The early detection of cardiac syncope is challenging. We aimed to evaluate the diagnostic value of 4 novel prohormones, quantifying different neurohumoral pathways, possibly involved in the pathophysiological features of cardiac syncope ...
Badertscher, Patrick, Boeddinghaus, Jasper, Buser, Andreas, Bustamante, José, Christ, Michael, Cullen, Louise, de Lavallaz, Jeanne du Fay, Di Somma, Salvatore, Flores, Dayana, Frank Peacock, W., Geigy, Nicolas, Giménez, Maria Rubini, Javier Martin-Sanchez, F., Kawecki, Damian, Keller, Dagmar I., Kloos, Wanda, Kozhuharov, Nikola, Kuehne, Michael, Lohrmann, Jens, López, Beatriz, Miró, Oscar, Morawiec, Beata, Mueller, Christian, Nestelberger, Thomas, Osswald, Stefan, Poepping, Imke, Puelacher, Christian, Reichlin, Tobias, Rentsch, Katharina, Sabti, Zaid, Sarasin, François, Shrestha, Samyut, Strebel, Ivo, Than, Martin, Tschuck, Michael, Twerenbold, Raphael, Wildi, Karin   +36 more
core   +1 more source