Results 61 to 70 of about 32,445 (282)

Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models

Nature Communications
Sinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu, Yangxi Zeng, Wei Fan, Xi Lan, Can Liu, Yisong He, Zhaoting Li, Kewei Jia, Juyi Wan, Bin Liao   +9 more
doaj   +1 more source

Intrinsic Versus Extrinsic Sinus and Atrioventricular Nodes Dysfunction in Athletes: Insights From Transesophageal Electrophysiological Testing With Autonomic Blockade

Reviews in Cardiovascular Medicine
Background: While sinus bradycardia and atrioventricular (AV) block in athletes have traditionally been viewed as benign consequences of enhanced vagal tone, recent evidence suggests that, in some individuals, nodal dysfunction may be ...
Sergei Bondarev, Domenico Corrado, Alessandro Zorzi   +2 more
doaj   +1 more source

Transcatheter Repair of Sinus Venosus Defect Using a 12‐zig Covered Cheatham‐Platinum Stent in Large Superior Vena Cava—Right Atrium Junctions: Early Multicenter Experience

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Sinus venosus defect (SVD) is a rare congenital heart anomaly characterised by an abnormal communication between the atria, often associated with partial anomalous pulmonary venous connection (PAPVC). Traditional surgical repair carries significant risks, prompting exploration into less invasive transcatheter approaches.
Alberto Fuensalida, Eric Rosenthal, Saleha Kabir, Gergely Szantho, Sophia Yong, Demetris Taliotis, Mark Turner, Radwa Bedair   +7 more
wiley   +1 more source

The Hidden Rhythm: A Rare Case of Isoarrhythmic Sick Sinus Syndrome Defying Chronotropic Expectations

International Journal of Medical Students
Background: Isoarrhythmic sick sinus syndrome (SSS) is a rare and often under-recognized variant of sinus node dysfunction, where the sinus and junctional rates are nearly identical, masquerading as a normal rhythm.
Tooba Fatima Iram, Haroon Abdullah Shaheed, Yusra Fatima Anam, Rahul Kumar Agarwal, Naazira Begum   +4 more
doaj   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Generation of a patient-specific hiPS cell line with heterozygous GNB2 mutation (UKMi003-A) causative for human sinus node dysfunction and a corresponding CRISPR/Cas9-corrected isogenic control (UKMi004-A)

Stem Cell Research
The heterozygous mutation c.155G > T in GNB2 clinically leads to sinus bradycardia and sinus node dysfunction. Here, patient-specific skin fibroblasts of the mutation carrier were used for Sendai virus reprogramming into human induced-pluripotent stem ...
Anne Kayser, Sven Dittmann, Jassin Hamidi, Sandra D. Laufer, Ramona Krampe, Giulia Mearini, Arne Hansen, Eric Schulze-Bahr   +7 more
doaj   +1 more source

The Evolution of Sinoatrial Node Function in Man [PDF]

, 1973
The function of the sinoatrial node is complex. In nearly all hearts, this small bit of tissue is responsible for spontaneously generating the impulse which will be distributed to the remainder of the heart, maintaining coordinated electrical and ...
Bigger, J. Thomas, Strauss, Harold C.
core   +1 more source

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

Diastolic And Systolic Right Ventricular Dysfunction Precedes Left Ventricular Dysfunction In Patients Paced From Right Ventricular Apex [PDF]

, 2006
Background: Cardiac dysfunction after right ventricular (RV) apical pacing is well known but its extent, time frame of appearance and individual effect on left ventricular (LV), RV systolic and diastolic parameters has not evaluated in a systematic ...
Bansal, Sandeep, M, Hasan, MK, Makharia, Puri, Aniket, RK, Saran, SK, Dwivedi, VK, Puri, VS, Narain   +7 more
core  

SINUS NODE DYSFUNCTION IN CHILDREN [PDF]

Pediatric Research, 1977
Over a three year period, 30 pedlatric patients (pts) with electrocardiographic evidence of sinus node dysfunction (SND) were identified. Their ages ranged from 3 days to 21 years. Twenty-two pts had significant heart disease. In 13, the onset of SND followed corrective cardiac surgery, and of these, 8 were operations for atrial septal defect and ...
Steven M Yabek, Robert E Greenberg
openaire   +1 more source