Results 41 to 50 of about 1,139,613 (186)

Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models

Nature Communications
Sinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu, Yangxi Zeng, Wei Fan, Xi Lan, Can Liu, Yisong He, Zhaoting Li, Kewei Jia, Juyi Wan, Bin Liao   +9 more
doaj   +1 more source

Intrinsic Versus Extrinsic Sinus and Atrioventricular Nodes Dysfunction in Athletes: Insights From Transesophageal Electrophysiological Testing With Autonomic Blockade

Reviews in Cardiovascular Medicine
Background: While sinus bradycardia and atrioventricular (AV) block in athletes have traditionally been viewed as benign consequences of enhanced vagal tone, recent evidence suggests that, in some individuals, nodal dysfunction may be ...
Sergei Bondarev, Domenico Corrado, Alessandro Zorzi   +2 more
doaj   +1 more source

Genetic Na+ channelopathies and sinus node dysfunction

, 2008
Voltage-gated Na+ channels are transmembrane proteins that produce the fast inward Na+ current responsible for the depolarization phase of the cardiac action potential. They play fundamental roles in the initiation, propagation, and maintenance of normal
Zhang, Yanmin, Lei, Ming, Huang, Christopher L H   +2 more
core   +1 more source

The Hidden Rhythm: A Rare Case of Isoarrhythmic Sick Sinus Syndrome Defying Chronotropic Expectations

International Journal of Medical Students
Background: Isoarrhythmic sick sinus syndrome (SSS) is a rare and often under-recognized variant of sinus node dysfunction, where the sinus and junctional rates are nearly identical, masquerading as a normal rhythm.
Tooba Fatima Iram, Haroon Abdullah Shaheed, Yusra Fatima Anam, Rahul Kumar Agarwal, Naazira Begum   +4 more
doaj   +1 more source

Permanent pacemaker implantation in unexplained syncope patients with borderline sinus bradycardia and electrophysiology study‐proven sinus node disease

Journal of Arrhythmia, 2021
Background Significant sinus bradycardia (SB) in the context of sinus node dysfunction (SND) has been associated with neurological symptoms. The objective was to evaluate the effect of permanent pacing on the incidence of syncope in patients with rather ...
Ioannis Doundoulakis, Konstantinos A. Gatzoulis, Petros Arsenos, Polychronis Dilaveris, Ioannis Skiadas, Dimitrios Tsiachris, Christos‐Konstantinos Antoniou, Stergios Soulaidopoulos, George Karystinos, Voula Pylarinou, Maria Drakopoulou, Skevos Sideris, Charalambos Vlachopoulos, Dimitrios Tousoulis   +13 more
doaj   +1 more source

Generation of a patient-specific hiPS cell line with heterozygous GNB2 mutation (UKMi003-A) causative for human sinus node dysfunction and a corresponding CRISPR/Cas9-corrected isogenic control (UKMi004-A)

Stem Cell Research
The heterozygous mutation c.155G > T in GNB2 clinically leads to sinus bradycardia and sinus node dysfunction. Here, patient-specific skin fibroblasts of the mutation carrier were used for Sendai virus reprogramming into human induced-pluripotent stem ...
Anne Kayser, Sven Dittmann, Jassin Hamidi, Sandra D. Laufer, Ramona Krampe, Giulia Mearini, Arne Hansen, Eric Schulze-Bahr   +7 more
doaj   +1 more source

Bradyarrhythmia in Hospitalized Patients With SARS‐CoV‐2 Infection: A Systematic Scoping Review and Clustering Analyses

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Among arrhythmias observed in SARS‐CoV‐2 infection, bradyarrhythmia poses the dilemma of urgent pacing. In this population, data on patients' characteristics and clinical outcomes are lacking.
Federico Blasi, Margherita Casiraghi, Matteo Morello, Carlo Arnò, Michele Golino, Elisa Franceschi, Gianfranco Alicandro, Marco Vicenzi, Roberto De Ponti   +8 more
doaj   +1 more source

SINUS NODE DYSFUNCTION IN CHILDREN [PDF]

Pediatric Research, 1977
Over a three year period, 30 pedlatric patients (pts) with electrocardiographic evidence of sinus node dysfunction (SND) were identified. Their ages ranged from 3 days to 21 years. Twenty-two pts had significant heart disease. In 13, the onset of SND followed corrective cardiac surgery, and of these, 8 were operations for atrial septal defect and ...
Steven M Yabek, Robert E Greenberg
openaire   +1 more source

Acute Pulmonary Hypertension Secondary to Right Ventricular Pacing in a Patient With Sinus Node Dysfunction and Severe Ischemic Cardiomyopathy

, 2005
Right ventricular pacing has been associated with worsening symptoms of heart failure in patients with cardiomyopathy. We describe a patient with severe ischemic cardiomyopathy and sinus node dysfunction who developed acute worsening of pulmonary ...
Javier Jimenez, Rechani, Luis, Speziani, Giancarlo H, Alberto Interian, Interian, Jr, Alberto, Myerburg, Robert, Luis Rechani, Stephen Mallon, Robert Myerburg, Jimenez, Javier, Giancarlo H. Speziani, Mallon, Stephen   +11 more
core   +1 more source

Brugada syndrome and sinus node dysfunction

Journal of Arrhythmia, 2018
AbstractBrugada syndrome (BrS) is a well‐known catastrophic disease first reported in 1992 by the Brugada brothers. Ventricular fibrillation (VF) is an essential arrhythmia in BrS. An association between BrS and atrial tachyarrhythmias is not uncommon. However, sinus node dysfunction (SND) associated with BrS has not been well discussed. In this review,
Hidemori Hayashi, Masataka Sumiyoshi, Yuji Nakazato, Hiroyuki Daida   +3 more
openaire   +2 more sources