Results 31 to 40 of about 18,477 (242)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Sinus Node Dysfunction as the First Manifestation of Left Ventricular Noncompaction with Multiple Cardiac Abnormalities

Indian Pacing and Electrophysiology Journal, 2013
Left ventricular noncompaction (LVNC) is a genetically heterogenous form of cardiomyopathy which may remain undiagnosed till adulthood due to the late presentation of typical symptoms such as dyspnea, congestion, ventricular arrhythmias and ...
Baris Gungor, MD, Ahmet T. Alper, MD, Ahmet Celebi, MD, Osman Bolca, MD   +3 more
doaj   +1 more source

H1N1-associated sinus node dysfunction [PDF]

Heart Asia, 2015
A 51-year-old previously healthy man presented to the emergency room following an episode of presyncope. He had a history of fever, pleuropericardial chest pain and dyspnoea accompanied by important myalgia evolving over several days. His past medical history was negative for any cardiovascular or pulmonary disease, and he was a lifelong non-smoker. He
Christian, Steinberg, Santabhanu, Chakrabarti   +1 more
openaire   +2 more sources

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

A Case of Kawasaki Disease Accompanied by Encephalitis and Several Kinds of Arrhythmia during the Acute Phase

Case Reports in Pediatrics, 2019
Although central nervous system complications occasionally accompany during the acute phase of Kawasaki disease, clinically problematic arrhythmia is quite rare.
Naomi Nakagawa, Masahiro Kamada, Yukiko Ishiguchi, Yuji Moritoh, Kengo Okamoto, Shinji Itamura   +5 more
doaj   +1 more source

Characteristics of Anal Fistula Cancer in Patients Who Underwent Surgery: A Nationwide Observational Study Using Diagnosis Procedure Combination Data

Annals of Gastroenterological Surgery, EarlyView.
The characteristics of patients with anal fistula cancer included a higher proportion of men, younger age, more smokers, and tumor‐related characteristics, including more advanced local progression. Surgical characteristics included a lower rate of minimally invasive surgery, a higher proportion of total pelvic exenterations, and longer postoperative ...
Nobuaki Hoshino, Hiromitsu Kinoshita, Kazutaka Obama, Kiyohide Fushimi, Susumu Kunisawa, Yuichi Imanaka   +5 more
wiley   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Effect of Laser Posterior Nasal Neurolysis for the Treatment of Chronic Rhinitis: A Randomized Controlled Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background To determine the safety and efficacy of laser ablation of the posterior nasal nerve (PNN) for the treatment of chronic rhinitis. Methods This study was a single‐center, prospective, single‐blinded, randomized sham‐controlled trial. Patients with a 24‐h reflective Total Nasal Symptom Score (rTNSS) ≧ 5, rhinorrhea ≧ 2, and congestion ≧
Jyun‐Yi Liao, En‐Ying Wang, Ying‐Shuo Hsu, Ming‐Shao Tsai, Cheng‐Jung Wu, Chia‐Hao Chang, Yi‐Li Hwang, Han‐Lo Teng, Jun‐Wei Hsieh, Chien‐Yu Huang   +9 more
wiley   +1 more source

Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models

Nature Communications
Sinus node dysfunction, a prevalent arrhythmia in aging populations, is characterized by fibrosis and loss of pacemaker activity, necessitating pacemaker implantation. Current therapies fail to reverse the underlying pathology.
Hanfeng Liu, Yangxi Zeng, Wei Fan, Xi Lan, Can Liu, Yisong He, Zhaoting Li, Kewei Jia, Juyi Wan, Bin Liao   +9 more
doaj   +1 more source

Intrinsic Versus Extrinsic Sinus and Atrioventricular Nodes Dysfunction in Athletes: Insights From Transesophageal Electrophysiological Testing With Autonomic Blockade

Reviews in Cardiovascular Medicine
Background: While sinus bradycardia and atrioventricular (AV) block in athletes have traditionally been viewed as benign consequences of enhanced vagal tone, recent evidence suggests that, in some individuals, nodal dysfunction may be ...
Sergei Bondarev, Domenico Corrado, Alessandro Zorzi   +2 more
doaj   +1 more source