Results 91 to 100 of about 62,260 (164)

Dasatinib Associated Pleural Complications‐ A Case Series

Respirology Case Reports, Volume 14, Issue 3, March 2026.
Dasatinib is an effective therapy for chronic myeloid leukaemia but may lead to pleural complications, including exudative effusions and rare chylothorax. This case series describes four patients who developed pleural effusions after long‐term dasatinib therapy, highlighting successful management through dose reduction or TKI switching.
Vishnu Vazhoor, Shruthi Keechilat Pavithran, Manoj Unni, Asmita Mehta, Keechilat Pavithran   +4 more
wiley   +1 more source

Prospective study of safety, immunogenicity, and efficacy of inactivated COVID-19 vaccine in tuberous sclerosis complex children on sirolimus

Human Vaccines & Immunotherapeutics
While sirolimus is widely used in tuberous sclerosis complex (TSC), its impact on coronavirus disease 2019 (COVID-19) vaccination remains unclear. To evaluate the safety, immunogenicity, and efficacy of inactivated COVID-19 vaccine on the children with ...
Sufang Lin, Xia Zhao, Lin Li, Qiru Su, Weiwei Long, Xiaoqin Tian, Jinghua Ye, Bixia Yuan, Yan Hu, Jianxiang Liao, Hongbing Zhang   +10 more
doaj   +1 more source

Preventative treatment of tuberous sclerosis complex with sirolimus: Phase I safety and efficacy results

Annals of the Child Neurology Society
Objective Tuberous sclerosis complex (TSC) results from overactivity of the mechanistic target of rapamycin (mTOR). Sirolimus and everolimus are mTOR inhibitors that treat most facets of TSC but are understudied in infants.
Jamie K. Capal, David M. Ritter, David Neal Franz, Molly Griffith, Kristn Currans, Bridget Kent, E. Martina Bebin, Hope Northrup, Mary Kay Koenig, Tomoyuki Mizuno, Alexander A. Vinks, Stephanie L. Galandi, Wujuan Zhang, Kenneth D.R. Setchell, Kelly M. Kremer, Carlos M. Prada, Hansel M. Greiner, Katherine Holland‐Bouley, Paul S. Horn, Darcy A. Krueger   +19 more
doaj   +1 more source

Dysmorphic neurons express markers of inhibitory glycinergic signaling in focal cortical dysplasia IIb

Brain Pathology, Volume 36, Issue 2, March 2026.
Deep learning tissue mapping can guide region of interest selection for spatial transcriptomic analyses. Using this method, a transcriptional catalogue of focal cortical dysplasia type IIb was generated, revealing enrichment for markers of inhibitory glycinergic signaling in cytomegalic dysmorphic neurons.
Ameesha Paliwal, Kevin Faust, Okty Abbasi Borhani, Mugeng Liu, Lauren Omoto, Evelyn Rose Kamski‐Hennekam, Parsa Babaei Zadeh, Rifat Shahriar Sajid, Phedias Diamandis   +8 more
wiley   +1 more source

A UK key opinion leader perspective: Navigating the immunological and logistical transformation brought by stem cell‐derived islets for the treatment of type 1 diabetes

Diabetic Medicine, Volume 43, Issue 3, March 2026.
Abstract Aims To explore UK key‐opinion leader perspectives on the future role of stem cell‐derived islets (sc‐islets) in islet transplantation for people with type 1 diabetes (T1D). Methods Four UK‐based key‐opinion leaders evaluated current limitations of donor islet transplantation and reviewed emerging evidence, clinical pathways and logistical ...
Thomas Strakosch, Shareen Forbes
wiley   +1 more source

Clinical outcomes following stereotactic MRI‐guided laser ablation in children with tuberous sclerosis complex and intractable epilepsy

Epilepsia, Volume 67, Issue 3, Page 1169-1180, March 2026.
Abstract Objective In children with tuberous sclerosis complex (TSC) and drug‐resistant epilepsy (DRE), magnetic resonance imaging–guided stereotactic laser ablation (SLA) therapy offers less‐invasive treatment compared to craniotomy and resection. Our study seeks to further expand on the long‐term outcomes in patients with TSC‐related DRE who have ...
Chelsey Ortman, Rohini Coorg, Irfan Ali, Dave Clarke, Gloria Diaz‐Medina, Kimberly Houck, Akshat Katyayan, Laura Masters, Deepankar Mohanty, Anuranjita Nayak, Michael Quach, Vijay M. Ravindra, James J. Riviello, Sonali Sen, Elaine Seto, Danielle Takacs, Cristina Trandafir, John T. Freiling, Karen Evankovich, Yingchao Yuan, Kalman A. Katlowitz, Daniel Curry, Howard L. Weiner, Anne Anderson   +23 more
wiley   +1 more source

Association Between Solid Organ Transplantation and Oral Candidiasis: A Systematic Review and Meta‐Analysis

Special Care in Dentistry, Volume 46, Issue 2, March/April 2026.
ABSTRACT Aim To summarize the evidence on the association of oral candidiasis with solid organ transplantation in case‐control and cohort studies. Methods The quality of studies was assessed using the Newcastle–Ottawa scale. Random‐effects restricted maximum likelihood model or Fixed‐effects Mantel–Haenszel models were used to pool the results ...
Neha Shah, Sangeeta Sinha, Abhay Sonthalia, Divesh Sardana   +3 more
wiley   +1 more source

Sirolimus <i>vs</i> paclitaxel-coated balloons in in-stent coronary restenosis: A meta-analysis. [PDF]

World J Methodol
Mandal D, Pulickal TV, Ahlawat D, Haqbeen W, Kashif I, Alamy H, Prattipati P, Jaladi P, Kabiaru P, Avula A, Kshetri S, Raza I, Shamieh S, Chhetri R.   +13 more
europepmc   +1 more source

Angiographic and functional assessment after paclitaxel or sirolimus drug-coated balloons for de novo coronary artery disease in small vessels: PICCOLETO VI study. [PDF]

AsiaIntervention
Fezzi S, Gitto M, Trevisanello A, Sharif F, Venturi G, Bezubka J, Iwanczyk S, Wanha W, Hawranek M, Mielczarek M, Wańczura P, Verdoia M, Pieri P, Mugnolo A, Khialani B, Litovchik I, Monayer A, Rissanen TT, Ribichini F, Colombo A, Cortese B.   +20 more
europepmc   +1 more source

Effective treatment with sirolimus in a 6-year-old boy with tracheal vascular malformation initially misdiagnosed as acute laryngitis: a case report. [PDF]

J Med Case Rep
Zhang M, Cai X.
europepmc   +1 more source