Results 91 to 100 of about 82,161 (336)
Safety and efficacy of low-dose sirolimus in the PIK3CA-related overgrowth spectrum
Genetics in Medicine, 2018 PIK3CA-related overgrowth spectrum (PROS) encompasses a range of debilitating conditions defined by asymmetric overgrowth caused by mosaic activating PIK3CA variants.
V. Parker +30 more
semanticscholar +1 more source
Sirolimus in the Treatment of Vascular Anomalies [PDF]
European Journal of Pediatric Surgery, 2016 Aim of the Study mTOR inhibitors are showing promising results in the management of vascular anomalies. Although current controlled trials remain to be completed, many individual experiences are being published. We present our series of children with complex vascular anomalies treated with sirolimus.
Juan Carlos López-Gutiérrez +7 more
openaire +2 more sources
, 2014 Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression.
Burroughs, AK +2 more
core
Experimental rat models of chronic allograft nephropathy: a review [PDF]
, 2014 Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core +2 more sources
Medications, epilepsy and climate change: Added layers of complexity
British Journal of Clinical Pharmacology, EarlyView.Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi +2 more
wiley +1 more source
Alimentary Pharmacology and Therapeutics, 2019 Calcineurin‐inhibitor immunosuppressants (tacrolimus and ciclosporin) have been associated with an exposure‐related increase in tumour recurrence following liver transplantation for hepatocellular carcinoma (HCC).
S. Grigg, G. Sarri, P. Gow, N. Yeomans
semanticscholar +1 more source
BMEMat, EarlyView.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
On the role of specific drug binding in modelling arterial eluting stents [PDF]
, 2016 In this paper we consider drug binding in the arterial wall following delivery by a drug-eluting stent. Whilst it is now generally accepted that a non-linear saturable reversible binding model is required to properly describe the binding process, the ...
AR Tzafriri +13 more
core +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Coronary stent fractures (SFs) are an emerging complication of coronary stents. There are numerous risk factors for SF, which include vessel angulation, use of sirolimus‐eluting stent (SES), long stents, multiple stent layers, stent overlap, inflammation, hypersensitivity, stenting in the right coronary artery, heavy calcification, ostial ...
Kosuke Muto +3 more
wiley +1 more source
Clinical and Translational ScienceDose optimization of sirolimus may further improve outcomes in allogeneic hematopoietic cell transplant (HCT) patients receiving post‐transplantation cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD).
Ezhilpavai Mohanan +11 more
doaj +1 more source