Results 71 to 80 of about 91,272 (228)

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Low-Dose Sirolimus Immunoregulation Therapy in Patients with Active Rheumatoid Arthritis: A 24-Week Follow-Up of the Randomized, Open-Label, Parallel-Controlled Trial

Journal of Immunology Research, 2019
Background. We have reported previously the insufficient absolute number or functional defects of regulatory T cells (Tregs) in patients with rheumatoid arthritis (RA), challenging conventional unspecific immunosuppressive therapy.
Hong-Yan Wen, Jia Wang, Sheng-Xiao Zhang, Jing Luo, Xiang-Cong Zhao, Chen Zhang, Cai-Hong Wang, Fang-Yuan Hu, Xiao-Juan Zheng, Ting Cheng, Hong-Qing Niu, Guang-Ying Liu, Wen-Xian Yang, Na-Na Yu, Jin-Li Ru, Qi-Xiang Chen, Xue-Chun Lu, Pei-Feng He, Chong Gao, Xiao-Feng Li   +19 more
doaj   +1 more source

A liver transplant patient developed renal injury on tacrolimus and experienced worsening renal function and rhabdomyolysis after switching to sirolimus: a case report

BMC Nephrology
Renal impairment and rhabdomyolysis are rare in transplant patients receiving sirolimus. We report the case of a 54-year-old male who underwent liver transplantation and was initially treated with tacrolimus, mycophenolate mofetil, and glucocorticoids ...
Chang Gao, Zhi-Yu Chen, Liang Ma, Shen-Ju Gou   +3 more
doaj   +1 more source

Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells

BMC Cardiovascular Disorders, 2005
Background Sirolimus-eluting stents (CYPHER stents) demonstrated remarkable efficacy in reducing restenosis rates in patients with coronary artery disease. There is a concern of sub-acute and late stent thrombosis.
Ming Xiu-Fen, Gajanayake Thusitha, Viswambharan Hema, Zhu Shengsi, Yang Zhihong   +4 more
doaj   +1 more source

Alemtuzumab preconditioning with tacrolimus monotherapy - The impact of serial monitoring for donor-specific antibody [PDF]

, 2008
BACKGROUND. Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning. METHODS.
Adriana Zeevi, Alin L. Girnita, Amadeo Marcos, Amit Basu, Calne, Deanna M. Blisard, Edward A. Gray, Girnita, Henkie P. Tan, Kirk, Knechtle, Kowalski, Liise K. Kayler, Mao, Meier-Kriesche, Mizutani, Montgomery, Ngoc L. Thai, Parmjeet S. Randhawa, Pascual, Pei, Ron Shapiro, Shapiro, Shapiro, Shapiro, Starzl, Stuart, Tan, Thomas E. Starzl, Waldmann   +29 more
core   +1 more source

Standardized Management Pathway to Prevent Acute Rejection After Liver Transplantation Following ICI Therapy for Downstaging HCC

Health Care Science, EarlyView.
Findings indicate that within a standardized clinical pathway integrating structured immunosuppression, therapeutic drug monitoring, and early complication surveillance, liver transplantation after ICI exposure can be performed safely without increased rejection risk.
Ning Wang, Zebin Zhu, Hao Zheng, Can Qi, Xiaodong Yuan, Xuefeng Li, Zhijun Xu, Jiwei Qin, Wei Wu, Jizhou Wang, Ruipeng Song, Zhiyong Guo, Lianxin Liu, Shu‐Geng Zhang, Björn Nashan   +14 more
wiley   +1 more source

Next-generation sequencing of prostate cancer: genomic and pathway alterations, potential actionability patterns, and relative rate of use of clinical-grade testing. [PDF]

, 2019
Despite being one of the most common cancers, treatment options for prostate cancer are limited. Novel approaches for advanced disease are needed. We evaluated the relative rate of use of clinical-grade next generation sequencing (NGS) in prostate cancer,
Carter, Jennifer L, Elkin, Sheryl K, Ikeda, Sadakatsu, Kurzrock, Razelle, Tomson, Brett N   +4 more
core  

Emotions and scope effects in the monetary valuation of health [PDF]

, 2018
JEL classifications: H41 H51 I11 I18 I31This study presents evidence on the role of emotions in the monetary evaluation of health technologies, namely, drug-eluting stents (DES) in our case.
Araña, Jorge, Avilés Blanco, Maria V., Brey, Raúl, Pinto Prades, Jose Luis   +3 more
core   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source