Results 71 to 80 of about 70,065 (194)

Drug Critical Limits for Urgent Physician Notification

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 178-192, July 2026.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang   +3 more
wiley   +1 more source

Sirolimus-Induced Hepatitis in Two Patients with Hyperinsulinemic Hypoglycemia

open access: yes, 2018
Sirolimus has been reported to be effective in the treatment of the diffuse form of congenital hyperinsulinism (CHI), unresponsive to diazoxide and octreotide, without causing severe side effects.
Mehmet Nuri Özbek   +13 more
core   +1 more source

Liver Transplantation for HBV‐Related Disease in France: NUC Type Before LT Is Associated With Patient Survival

open access: yesLiver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background & Aims Liver transplantation (LT) is indicated for liver complications related to hepatitis B virus (HBV) infection: acute liver failure (ALF), decompensated cirrhosis or hepatocellular carcinoma (HCC). The present study aimed to describe and evaluate patient survival after LT for HBV‐related disease in France and identify the ...
Isaure Bienvenue   +28 more
wiley   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

open access: yesBrain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence   +14 more
wiley   +1 more source

IVUS‐Guided Versus Angiography‐Guided PCI for Unprotected Left Main Coronary Artery Disease: A Systematic Review, Meta‐Analysis, and GRADE Assessment of Randomized Trials

open access: yesClinical Cardiology, Volume 49, Issue 6, June 2026.
graphical abstract for IVUS‐guided versus angiography‐guided pci for unprotected left main coronary artery disease. ABSTRACT Background Intravascular ultrasound (IVUS) has been increasingly used as an adjunctive tool for complex percutaneous interventions (PCIs); however, comparative randomized evidence with conventional angiography in unprotected left
Abdelrahman Elhakim   +9 more
wiley   +1 more source

Development and Retrospective Application of Novel Outcome Measure: Sturge–Weber Syndrome Acute Crisis (SWAC) Index

open access: yesAnnals of the Child Neurology Society, Volume 4, Issue 2, Page 132-139, June 2026.
ABSTRACT Objective Sturge–Weber syndrome (SWS) symptoms frequently overlap in neurological acute crises (ACs) presenting with seizures, stroke‐like episodes (SLE), and headaches. Recent efforts to develop a prospective drug trial highlighted the need for a new outcome measure capable of quantifying these symptoms during an SWS AC.
Kieran D. McKenney   +3 more
wiley   +1 more source

Sirolimus and mirabegron interaction in a hematopoietic cell transplant patient

open access: yes, 2017
Purpose Hematopoietic cell transplant patients are exposed to numerous classes of medications. Transplant practitioners must vigilantly monitor for drug interactions especially involving immunosuppressants.
Jeff A Engle, Christina Fair
core   +1 more source

Voriconazole and Sirolimus Coadministration after Allogeneic Hematopoietic Stem Cell Transplantation

open access: yes, 2006
Sirolimus is increasingly used in transplantation for prevention and treatment of graft-versus-host disease and organ rejection. Voriconazole is contraindicated when used concomitantly with sirolimus because of a substantial increase in sirolimus drug ...
Lowry, Colleen M.   +6 more
core   +1 more source

Standardized Management Pathway to Prevent Acute Rejection After Liver Transplantation Following ICI Therapy for Downstaging HCC

open access: yesHealth Care Science, Volume 5, Issue 3, Page 196-206, June 2026.
Findings indicate that within a standardized clinical pathway integrating structured immunosuppression, therapeutic drug monitoring, and early complication surveillance, liver transplantation after ICI exposure can be performed safely without increased rejection risk.
Ning Wang   +14 more
wiley   +1 more source

Topical sirolimus in dermatology: a systematic review

open access: yes
Topical sirolimus is increasingly utilized off-licence to manage various dermatological conditions while avoiding typical adverse effects associated with systemic sirolimus.
Afzal, Usamah M   +4 more
core   +1 more source

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