Results 61 to 70 of about 91,272 (228)

Functional improvements in patients with lymphangioleiomyomatosis after sirolimus: an observational study

Orphanet Journal of Rare Diseases, 2018
Background Sirolimus has been shown to be effective in patients with lymphangioleiomyomatosis (LAM). We wish to summarize our experience using sirolimus and its effectiveness in LAM patients.
Yongzhong Zhan, Lisha Shen, Wenshuai Xu, Xiuxiu Wu, Weihong Zhang, Jun Wang, Xue Li, Yanli Yang, Xinlun Tian, Kai-Feng Xu   +9 more
doaj   +1 more source

Sirolimus-Induced Rash in a Kidney Transplant Patient

European Journal of Case Reports in Internal Medicine, 2022
Sirolimus is an inhibitor of the mammalian target of rapamycin, which is used in kidney transplant immunosuppression. The clinical spectrum of cutaneous adverse events associated with sirolimus use varies, with maculopapular rash being an uncommon side ...
Zachary Bruss, Shanza Farook, Sana Shah, Abu Baker Sheikh   +3 more
doaj   +1 more source

Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating [PDF]

, 2018
In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the anti-proliferative drug docetaxel (DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21.
A Arsiwala, A Bierhalz, A Tan, AW Heldman, B Almería, B O’brien, B O’Brien, C Stettler, CJ Pan, CJ Sweeney, CL Song, D Sun, DM Saylor, E Boersma, E Camenzind, ES Park, ES Thian, F Danhier, GY An, H Zhang, HG Wang, J Kanzer, J Riegger, J Yang, J Zhang, JB Slee, JJ Wykrzykowska, JM Lee, JV Natarajan, K Kolandaivelu, KH Bønaa, KS Lim, M Gawaz, M Zamani, M Zamani, MK Dong, MP Skinner, MT Ali, PS Douglas, PW Erruys, RH Müller, RK Aggarwal, RL Wilensky, S Freiberg, S Garg, S Hossfeld, S Jang, S Lee, S Mcginty, S Meng, S Puricel, S Yasuda, SJ Liu, T Inoue, T Nakano, TM Ko, U Baber, X Ma, X Wu, X Xi, Y Cao, YH Lee, Z Yang   +62 more
core   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Sirolimus based immunosuppression is associated with need for early repeat therapeutic ERCP in liver transplant patients with anastomotic biliary stricture

Annals of Hepatology, 2013
Introduction. Sirolimus has inhibitory effects on epithelial healing and cholangiocyte regeneration. In liver transplantation (LT) patients, these effects may be greatest at the biliary anastomosis.
James H. Tabibian, M.D., Mohit Girotra, Hsin-Chieh Yeh, Dorry L. Segev, Murat T. Gulsen, Guldane Cengiz-Seval, Vikesh K. Singh, Andrew M. Cameron, Ahmet Gurakar   +8 more
doaj   +1 more source

Sirolimus Monotherapy for Thrombocytopenia in Primary Antiphospholipid Syndrome: A Pilot Study From a Tertiary Referral Center

Frontiers in Immunology, 2022
BackgroundThrombocytopenia (TP) is considered as a warning sign of high-risk antiphospholipid syndrome (APS) and sometimes a paradoxical sign of anti-thrombosis treatment.
Wenhui Xie, Lanlan Ji, Zhuoli Zhang
doaj   +1 more source

Stent implant follow-up in intravascular optical coherence tomography images [PDF]

, 2009
The objectives of this article are (i) to utilize computer methods in detection of stent struts imaged in vivo by optical coherence tomography (OCT) during percutaneous coronary interventions (PCI); (ii) to provide measurements for the assessment ...
Carlier, Stephane Guy, Gurmeric, Serhan, Gürmeriç, Serhan, Unal, Gozde, Ünal, Gözde   +4 more
core   +2 more sources

Development and Retrospective Application of Novel Outcome Measure: Sturge–Weber Syndrome Acute Crisis (SWAC) Index

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Sturge–Weber syndrome (SWS) symptoms frequently overlap in neurological acute crises (ACs) presenting with seizures, stroke‐like episodes (SLE), and headaches. Recent efforts to develop a prospective drug trial highlighted the need for a new outcome measure capable of quantifying these symptoms during an SWS AC.
Kieran D. McKenney, Luther G. Kalb, Adrienne M. Hammill, Anne M. Comi   +3 more
wiley   +1 more source

Challenges with sirolimus experimental data to inform QSP model of post‐transplantation cyclophosphamide regimens

Clinical and Translational Science
Dose optimization of sirolimus may further improve outcomes in allogeneic hematopoietic cell transplant (HCT) patients receiving post‐transplantation cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD).
Ezhilpavai Mohanan, Guofang Shen, Suping Ren, Hsuan‐Hao Fan, Kao Tang Ying Moua, Aleksandra Karolak, Russell C. Rockne, Ryotaro Nakamura, David A. Horne, Christopher G. Kanakry, Donald E. Mager, Jeannine S. McCune   +11 more
doaj   +1 more source

Pharmacokinetic analysis after implantation of everolimus-eluting self-expanding stents in the peripheral vasculature [PDF]

, 2012
Background: A novel self-expanding drug-eluting stent was designed to release everolimus 225 mu g/cm(2) to prevent restenosis following peripheral arterial intervention.
Hausegger, Klaus A, Koppensteiner, Renate, Lammer, Johannes, Mellon, Rajeev M, Scheinert, Dierk, Schroë, Herman, Schwartz, Lewis B, Vermassen, Frank   +7 more
core   +2 more sources