Results 41 to 50 of about 91,272 (228)

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. [PDF]

, 2014
Understanding genetic aberrations in cancer leads to discovery of new targets for cancer therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully described. Therefore, patients with refractory advanced/metastatic HCC referred
Janku, Filip, Kaseb, Ahmed O, Kurzrock, Razelle, Tsimberidou, Apostolia M, Wolff, Robert A   +4 more
core   +3 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Acute sirolimus overdose: a multicenter case series. [PDF]

PLoS ONE, 2015
There are few data relating to sirolimus overdose in the medical literature. Our objectives were to describe all cases of overdose with sirolimus reported to Swiss, German and Austrian Poisons Centres between 2002-2013.An observational case-series ...
Alessandro Ceschi, Elja Heistermann, Sonja Gros, Cornelia Reichert, Hugo Kupferschmidt, Nicholas R Banner, Stephan Krähenbühl, Anne B Taegtmeyer   +7 more
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Comparative acute toxicity of intravenous paclitaxel and sirolimus in rats

Current Research in Toxicology
Aim: In view of the exploration of sirolimus (rapamycin) as balloon coating for peripheral intravasal treatment and the reports on unfavorable tolerance of daily low-dose sirolimus, the aim of the study was to investigate potential toxicological effects ...
Jing Xie, Denise Schuett, Ulrich Speck, Tobias Haase   +3 more
doaj   +1 more source

Simulating Drug-Eluting Stents: Progress Made and the Way Forward [PDF]

, 2013
Drug-eluting stents have significantly improved the treatment of coronary artery disease. Compared with their bare metal predecessors, they offer reduced rates of restenosis and thus represent the current gold standard in percutaneous coronary ...
Kennedy, Simon, McCormick, Christopher, McGinty, Sean, McKee, Sean, Oldroyd, Keith G., Wheel, Marcus   +5 more
core   +2 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Low-dose oral sirolimus and the risk of menstrual-cycle disturbances and ovarian cysts: analysis of the randomized controlled SUISSE ADPKD trial. [PDF]

PLoS ONE, 2012
Sirolimus has been approved for clinical use in non proliferative and proliferative disorders. It inhibits the mammalian target of rapamycin (mTOR) signaling pathway which is also known to regulate ovarian morphology and function.
Matthias Braun, James Young, Cäcilia S Reiner, Diane Poster, Fabienne Krauer, Andreas D Kistler, Paulus Kristanto, Xueqi Wang, Yang Liu, Johannes Loffing, Gustav Andreisek, Arnold von Eckardstein, Oliver Senn, Rudolf P Wüthrich, Andreas L Serra   +14 more
doaj   +1 more source

Liver transplantation [PDF]

, 2014
Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression.
Burroughs, AK, De la Mata, M, Rodríguez-Perálvarez, M   +2 more
core  

Pancreas and islet cell transplantation [PDF]

, 2002
Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation.
A.N. Balamurugan, Alexander, Allen, Amos, Barber, Barrou, Bartlett, Björk, Bonner-Weir, Brekke, Calne, Calne, Cameron, Cheung, Chow, Corry, Diem, Diem, DiLandro, Fontes, Giannoukakis, Giannoukakis, Gibson, Gliedman, Grey, Groth, Groth, Gu, Gupta, Harris, Hayek, Henry, Ilieva, Kelly, Kemp, Kendall, Kendall, Keymeulen, Kirk, Koike, Koike, Lacy, Lafferty, Lakey, Lillehei, London, Massimo Trucco, Mazariegos, Mintz, Murray, Najarian, Nghiem, Paraskevas, Petruzzo, Piehlmeier, Pipeleers-Marichal, Posselt, Prevost, Rajotte, Ramiya, Ramos, Ricordi, Rita Bottino, Robertson, Shapiro, Simeonovic, Solders, Sollinger, Sollinger, Sollinger, Soria, Ssobolew, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Stone, Stratta, Stratta, Sutherland, Suzuki, Tchervenivanov, Terasaki, Thomas E. Starzl, Tyden, Tzakis, Yasunami   +94 more
core   +1 more source