Results 31 to 40 of about 91,272 (228)

Optimization of Initial Dose Regimen for Sirolimus in Pediatric Patients With Lymphangioma

Frontiers in Pharmacology, 2021
Sirolimus is an effective oral treatment for pediatric patients with lymphangioma. The present clinical study in 15 children (0.12–16.39 years of age) examines the effects of underlying factors on sirolimus concentrations through application of a ...
Xiao Chen, Dongdong Wang, Guangfei Wang, Yidie Huang, Xin Yu, Jinmiao Lu, Xiaowen Zhai, Hong Xu, Zhiping Li   +8 more
doaj   +1 more source

Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients

Journal of Lipid Research, 2002
Sirolimus (Rapammune®, rapamycin, RAPA) is a potent immunosuppressive drug that reduces renal transplant rejection. Hyperlipidemia is a significant side effect of sirolimus treatment, and frequently leads to cardiovascular disease.
Joel D. Morrisett, Ghada Abdel-Fattah, Ron Hoogeveen, Eddie Mitchell, Christie M. Ballantyne, Henry J. Pownall, Antone R. Opekun, Jonathon S. Jaffe, Suzanne Oppermann, Barry D. Kahan   +9 more
doaj   +1 more source

On the role of specific drug binding in modelling arterial eluting stents [PDF]

, 2016
In this paper we consider drug binding in the arterial wall following delivery by a drug-eluting stent. Whilst it is now generally accepted that a non-linear saturable reversible binding model is required to properly describe the binding process, the ...
AR Tzafriri, AR Tzafriri, CM Groh, DA Lauffenburger, F Bozsak, F Bozsak, G Frenning, G Pontrelli, GD Dangas, Giuseppe Pontrelli, RI Hickson, S McGinty, Sean McGinty, TTN Vo   +13 more
core   +1 more source

Avaliação da endotelização de hastes de stents em artérias ilíacas de coelhos Assessment of stent strut endothelialization in iliac arteries of rabbits

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A rápida endotelização pós-implante de stent é ocorrência desejável por teoricamente reduzir a possibilidade de trombose do stent. OBJETIVO: Avaliar a extensão da endotelização de hastes de stents eluidores de sirolimus (liberados da face ...
Celso Kiyochi Takimura, Ii-sei Watanabe, Francisco Rafael Martins Laurindo, Paulo Sampaio Gutierrez, Vera Demarchi Aiello, Spero Penha Morato, Pedro Alves Lemos Neto   +6 more
doaj   +3 more sources

A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma. [PDF]

, 2015
Hepatocellular carcinoma (HCC), the second leading cause of cancer deaths worldwide, is difficult to treat and highly lethal. Since HCC is predominantly diagnosed in patients with cirrhosis, treatment planning must consider both the severity of liver ...
Busuttil, Ronald W, Faltermeier, Claire, Zarrinpar, Ali   +2 more
core   +2 more sources

Pneumopathie médicamenteuse sous sirolimus : interaction avec l’atorvastatine ? [PDF]

, 2012
Introduction Sirolimus is an immunosupressant used in renal transplantation because of its lack of nephrotoxicity. We report four cases of pneumonitis due to sirolimus, possibly revealing an interaction with atorvastatin.
A. Foulet-Rogé, A. Paris, E. Kernaonet, F. Gagnadoux, F. Goupil, F.X. Lebas, O. Molinier   +6 more
core   +4 more sources

The use of sirolimus in patients with recurrent cytomegalovirus infection after kidney transplantation: A retrospective case series analysis

Saudi Journal of Kidney Diseases and Transplantation, 2019
Cytomegalovirus (CMV) is one of opportunistic infections post solid organ transplant and remains a cause of morbidity and mortality. Mammalian target of rapamycin inhibitors has a theoretical antiviral advantage compared to conventional immunosuppression.
Ali M Shendi, Rachel K. Y Hung, Ben Caplin, Paul Griffiths, Mark Harber   +4 more
doaj   +1 more source

Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex

Frontiers in Pharmacology, 2021
The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood level for seizure control in pediatric patients with tuberous sclerosis complex (TSC).
Xiao Chen, Dongdong Wang, Lin Zhu, Jinmiao Lu, Yidie Huang, Guangfei Wang, Yiqing Zhu, Qiaofeng Ye, Yi Wang, Hong Xu, Zhiping Li   +10 more
doaj   +1 more source

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in ...
Arcaro, Alexandre, Castelletti, Deborah, Fu, Xuebin, Liu, Yang, Mischak, Harald, Mullen, William, Pejchinovski, Martin, Serra, Andreas L., Siwy, Justyna, Wang, Xueqi, Watnick, Terry J.   +10 more
core   +2 more sources

mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma

Molecular Biomedicine
Sirolimus is a regularly applied immunosuppressant for patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Sirolimus not only significantly inhibits HCC recurrence but also protects renal function.
Lincheng Zhang, Peng Liu, Li Zhuang, Sunbin Ling, Qifan Zhan, Wei Zhou, Renyi Su, Lu Yin, Qingyang Que, Jiachen Hong, Jiaqi Bao, Chuxiao Shao, Jinzhen Cai, Shusen Zheng, Xiao Xu   +14 more
doaj   +1 more source