Results 11 to 20 of about 62,260 (164)
A Case Series of Lymphangioleiomyomatosis, a Rare Cystic Lung Disease. [PDF]
Respirol Case RepWe studied five women with a rare lung condition called LAM that typically affects only 1–5 women per 10 million. All patients had breathing difficulties and characteristic lung scans showing multiple thin‐walled air sacs. Finding five cases at one center in just 2 years suggests this condition might be more common than previously thought or often goes
Sedef S, Mutlu P.
europepmc +2 more sources
Pharmaceutics, 2021 Sirolimus is widely used in transplantation, where its therapeutic drug monitoring (TDM) is well established. Evidence of a crucial role for sirolimus in the PI3K/AkT/mTor pathway has stimulated interest in its involvement in neoplasia, either as ...
Amelia-Naomi Sabo +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Mammalian target of rapamycin (mTOR) inhibitors (sirolimus or everolimus) have been demonstrated effective in reducing the size of tuberous sclerosis complex (TSC)-associated retinal astrocytic hamartoma (RAH) in short term.
Chen-Xi Zhang +6 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2021 Background Patients with lymphangioleiomyomatosis (LAM) frequently experience pneumothorax. Although sirolimus is the standard therapy for LAM, its effect on pneumothorax is controversial.
Teiko Sakurai +8 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
CAQ Corner: Immune‐mediated complications
, 2022 Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley +1 more source
Molecules, 2015 The present study aimed to investigate the effect of Eudragit® E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral ...
Youngseok Cho +5 more
doaj +1 more source
Oral and Topical Sirolimus for Vascular Anomalies: A Multicentre Study and Review
Acta Dermato-Venereologica, 2019 Vascular anomalies (VAs) may be associated with significant morbidity and mortality. The aim of this study was to evaluate the efficacy and safety of sirolimus (rapamycin) in the treatment of children and young adults with complicated VAs.
Shira Sandbank +4 more
doaj +1 more source
Hematology Reports, 2023 The β-thalassemias are a group of monogenic hereditary hematological disorders caused by deletions and/or mutations of the β-globin gene, leading to low or absent production of adult hemoglobin (HbA).
Maria Rita Gamberini +5 more
doaj +1 more source
Similar trends in serum VEGF-D levels and kidney angiomyolipoma responses with longer duration sirolimus treatment in adults with tuberous sclerosis. [PDF]
PLoS ONE, 2013 We have previously shown that serum VEGF-D is elevated at baseline, correlates with kidney angiomyolipoma size at baseline and 12 months, and decreases with sirolimus treatment in adults with tuberous sclerosis complex (TSC).
Izabela A Malinowska +12 more
doaj +1 more source