Results 81 to 90 of about 40,880 (307)

Variables within NEWS, qSOFA and SIRS criteria.

, 2019
Variables within NEWS, qSOFA and SIRS criteria.
Hester Floor Lingsma (6263990), Robert Zietse (708989), Stephanie Catherine Elisabeth Schuit (6263993), Jelmer Alsma (6263981), Anniek Brink (6263978), Rob Johannes Carel Gerardus Verdonschot (6263984), Pleunie Petronella Marie Rood (6263987)   +6 more
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Частота возникновения SIRS среди пациентов перенесших торакотомию

, 2017
Arise of systemic inflammatory response syndrome (SIRS) can gravely complicate patients’ condition, leading to development of polyorgan insufficiency or immunosuppression with high probability of purulent complications as a result of compensatory CARS ...
Должковий, Сергій Вікторович, Прихідько, Роман Анатолійович, Dolzhkovyi, S. V., Шейко, Володимир Дмитрович, Каленюк, Дмитро Олександрович, Sheyko, V. D., Prykhidko, R. A., Каленюк, Дмитрий Александрович, Шейко, Владимир Дмитриевич, Должковой, Сергей Викторович, Прихидько, Роман Анатольевич, Kalenyuk, D. O.   +11 more
core   +1 more source

COVID-19 impact on thrombotic complications in cancer patients

Акушерство, гинекология и репродукция
Aim: to study the features of thrombotic complications in cancer patients during COVID-19 infection, and identify the most significant diagnostic and prognostic criteria.Materials and Methods.
A. V. Vorobev, S. E. Einullaeva, A. S. Borodulin, M. A. Shikina, S. A. Aliev, A. G. Solopova, V. N. Galkin, A. E. Ivanov, V. O. Bitsadze, J. Kh. Khizroeva, D. V. Blinov, J.-C. Gris, I. Elalamy, A. D. Makatsariya   +13 more
doaj   +1 more source

Effect of SIRS and sepsis on mortality in alcoholic hepatitis: A systematic review and meta-analysis

The Turkish Journal of Gastroenterology, 2016
Background/Aims: Sepsis is frequently observed in patients with alcoholic hepatitis (AH) and is an important mortality predictor. Several studies have also identified systemic inflammatory response syndrome (SIRS) as a significant prognostic factor.
Veeravich Jaruvongvanich, Anawin Sanguankeo, Sikarin Upala   +2 more
doaj   +1 more source

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

, 1995
OBJECTIVE: Define the epidemiology of the four recently classified syndromes describing the biologic response to infection: systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock.
Pittet, Didier, Costigan, M., Michele Costigan, Davis, C. S., M. Sigfrido Rangel-Frausto, Richard P. Wenzel, Hwang, T., Rangel-Frausto, M. S., Wenzel, R. P., Charles S. Davis, Taekyu Hwang, Didier Pittet   +11 more
core   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome

Journal of Veterinary Internal Medicine, 2017
Background Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown.
M.‐F. Roy, G.P.S. Kwong, J. Lambert, S. Massie, S. Lockhart   +4 more
doaj   +1 more source

SIRS/sepsis induces lymphopenia.

, 2014
SIRS induced by LPS or CpG causes marked, protracted leukopenia, whilst septic peritonitis does not. (A) SIRS or septic peritonitis was induced in mice as described.
Frank M. Brunkhorst (679258), Cynthia Weigel (679257), Katja Schubert (679256), Vladimir P. Badovinac (245681), Michael Bauer (115390), Robby Markwart (679253), Stephanie A. Condotta (679254), Thomas S. Griffith (333879), Ignacio Rubio (195279), Robert P. Requardt (368408), Farina Borken (679255), Martin Förster (157535)   +11 more
core   +1 more source