Results 201 to 210 of about 22,785 (248)

SIRT-1 Activity Sustains Cholesterol Synthesis in the Brain

Neuroscience, 2021
SIRT-1 is a potent energy regulator that has been implicated in the aging of different tissues, and cholesterol synthesis demands high amounts of cellular adenosine triphosphate.
Alejandro O Sodero
exaly   +2 more sources

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2-Anilinobenzamides as SIRT Inhibitors

ChemMedChem, 2006
Hidehiko Nakagawa, Takayoshi Suzuki, Naoki MIYATA   +2 more
exaly   +3 more sources

Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7

Protein Expression and Purification, 2023
SIRT6 and SIRT7, as members of the Sirtuins family, are indispensable for the growth and development of Drosophila. They play crucial roles in maintaining genome stability, regulating metabolic senescence, and controlling tumorigenesis. To investigate their involvement in the Drosophila life cycle, we focused on describing the expression and ...
Zhenhao, Wei, Jiejie, Zhu, Yafei, Cai, Ta, Liu, Xianghua, Ma, Xiaodie, Feng, Yaoyao, Wang, Yushan, Li, Wei, Zhang   +8 more
openaire   +2 more sources

Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma [PDF]

Digestive Diseases and Sciences, 2017
Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD(+))-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as metabolic syndromes, neurodegeneration, and ...
Mario Scartozzi, Casadei Gardini Andrea, Serena De Matteis   +2 more
exaly   +3 more sources

Computational Analysis and Improvement of SIRT

IEEE Transactions on Medical Imaging, 2008
Iterative X-ray computed tomography (CT) algorithms have the potential for producing high-quality images but are computationally very demanding, especially when applied to high-resolution problems. Focusing on simultaneous iterative reconstruction technique (SIRT), we provide an eigenvalue based scheme for automatically determining a near-optimal value
Jens Gregor, Thomas M. Benson
openaire   +3 more sources

Small Molecules as SIRT Modulators

Mini-Reviews in Medicinal Chemistry, 2018
Sirtuins are a family of NAD+-dependent deacetylases (class III histone deacetylases). Seven mammalian sirtuins, SIRT1-7, are identified, as the functions and locations differ greatly. SIRT1 and SIRT2 locate in nucleus and cytoplasm, while SIRT3-5 in mitochondria.
Xinfa, Bai, Lei, Yao, Xuan, Ma, Xiangming, Xu   +3 more
openaire   +2 more sources

SIRT: Planung, Durchführung, Dosimetrie

Angewandte Nuklearmedizin, 2023
ZusammenfassungDie Selektive Interne Radiotherapie (SIRT) ist ein nuklearmedizinisches Therapieverfahren zur Behandlung von Tumoren und Metastasen in der Leber. Dabei werden radioaktiv markierte Mikrosphären gezielt über einen Katheter in die Leberarterie injiziert, welche sich anschließend im Tumorgewebe anreichern. Dieser Übersichtsartikel soll einen
David Kästner, Enrico Michler
openaire   +1 more source

A pharmacological review on SIRT 1 and SIRT 2 proteins, activators, and inhibitors: Call for further research

International Journal of Biological Macromolecules, 2023
Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing an important part in the pathogenesis and treatment of various disorders. They have ubiquitously expressed protein deacetylases. They are implicated in several cellular activities like DNA repair, cellular metabolism, mitochondrial function, and inflammation.
Mukesh, Nandave, Rituparna, Acharjee, Kinkini, Bhaduri, Jyoti, Upadhyay, Gnana Prasoona, Rupanagunta, Mohd Nazam, Ansari   +5 more
openaire   +2 more sources

Methods of least squares and SIRT in reconstruction

Journal of Theoretical Biology, 1979
Abstract In this paper we show that a particular version of the Simultaneous Iterative Reconstruction Technique (SIRT) proposed by Gilbert in 1972 strongly resembles the Richardson least-squares algorithm. By adopting the adjustable parameters of the general Richardson algorithm, we have been able to produce generalized SIRT algorithms with improved
A V, Lakshminarayanan, A, Lent
openaire   +2 more sources

The Structured Interview for Renal Transplantation—SIRT

Psychosomatics, 2000
Despite the fact that the demand for psychiatric evaluations of organ transplant recipients is increasing, there is not a commonly agreed upon protocol that can guide clinicians. A standard psychiatric interview, although necessary, is not sufficient when interviewing transplant candidates.
D L, Mori, P, Gallagher, J, Milne
openaire   +2 more sources