Results 121 to 130 of about 29,404,625 (274)
KORELASI KADAR SIRTUIN-1 SERUM DENGAN KADAR TRANSFORMING GROWTH FACTOR-Β1 PADA PASIEN PENYAKIT GINJAL KRONIK [PDF]
Pendahuluan : Penyakit Ginjal Kronis (PGK) merupakan masalah kesehatan global dengan prevalensi yang terus meningkat dan tingkat mortalitas yang tinggi.
Retno, Eka Sari
core +1 more source
, 2014 Correction: Neurological and Histological Consequences Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly(ADP-ribose) Polymerase ...
PLOS ONE (2189197)
core +1 more source
Recent Advances in Top‐Down Proteomics for Single‐Cell Research
Mass Spectrometry Reviews, EarlyView.ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley +1 more source
, 2019 Amaç: İmplantasyon embriyonun maternal uterusa yerleşme sürecidir. Zigotun blastosiste gelişmesi ve uterusun reseptif hale gelmesinin senkronize olması kritik öneme sahiptir. Sirtuinler, yüksek derecede korunmuş histon/protein deasetilazlardır. Sirtuin 1
Aksu, Kübra
core
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1
, 2013 Embryonic development depends on complex and precisely orchestrated signaling pathways including specific reduction/oxidation cascades. Oxidoreductases of the thioredoxin family are key players conveying redox signals through reversible posttranslational
Dahl Ejby Jensen, Lasse, +14 more
core +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
Obesity, EarlyView.ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee +2 more
wiley +1 more source
Effect of combined training on gene expression of nuclear factor-κB and Sirtuin 1 in fast and slow twitch muscles in elderly male rats [PDF]
Medical Laboratory JournalBackground: The aim of this study is to investigate the effects of ten weeks of combined training on the gene expression of nuclear factor-κB and sirtuin 1 in fast and slow twitch muscles of aged male rats. Methods: Sixteen rats, each 24 months old, were
Hadi Yarahmadi +3 more
doaj
World Journal of Traditional Chinese MedicineObjective: NOD-like receptor protein 3 (NLRP3)-mediated pyroptosis is pivotal in the pathological development of cerebral ischemia/reperfusion injury (CIRI).
Ya-Nan Luo +5 more
doaj +1 more source
Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications
Portal Hypertension &Cirrhosis, EarlyView.This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf +8 more
wiley +1 more source