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Targeting Sirtuin 1 signaling pathway by ginsenosides
Journal of Ethnopharmacology, 2021Ginseng is a kind of traditional Chinese herbal medicine, known as "king of herbs" and widely used in China, South Korea, and other Asian countries. Ginsenosides are one of active components of Panax ginseng Meyer, which have many pharmacological effects, such as enhancing memory, improving immunity and cardiovascular system, delaying aging, and ...
Tingting Lou +4 more
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Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3
Mitochondrion, 2013In this review, we discuss the dual control of mitochondrial biogenesis and energy metabolism by silent information regulator-1 and -3 (SIRT1 and SIRT3). SIRT1 activates the peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α)-mediated transcription of nuclear and mitochondrial genes encoding for proteins promoting mitochondria ...
Julia, Brenmoehl, Andreas, Hoeflich
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Nephroprotective action of sirtuin 1 (SIRT1)
Journal of Physiology and Biochemistry, 2013Sirtuins, silent information regulator 2 (Sir 2) proteins, belong to the family of NAD(+)-dependent enzymes with deacetylase or mono-ADP-ribosyltransferase activity. These enzymes are responsible for processes of DNA repair or recombination, chromosomal stability and gene transcription.
Dorota, Polak-Jonkisz +5 more
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Viral genome silencing by neuronal sirtuin 1
Journal of NeuroVirology, 2010Neurotropic viruses remain dormant in sensory neurons for years, but upon reactivation, they can produce multiple disease states including pain symptoms. Latent viral DNA is extrachromosomal, maintained as a circular episome bound to histones.
Kelly E, Picchione, Arin, Bhattacharjee
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Role of Sirtuin 1 in metabolic regulation
Drug Discovery Today, 2010Sirtuin proteins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases. Originally discovered in yeast as gene-silencing proteins, they subsequently emerged as key regulators of life span in yeast and other lower species.
Jose P, Silva, Claes, Wahlestedt
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Sirtuin 1 in immune regulation and autoimmunity
Immunology & Cell Biology, 2011The NAD‐dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial biogenesis to neuronal development. Recent studies indicate that Sirt1 is a critical regulator of both the innate and adaptive immune response in mice and its altered functions are likely involved
Sinyi, Kong +2 more
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology, 2018
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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Nature Reviews Molecular Cell Biology, 2016Michael S Bonkowski, David A Sinclair
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Nature, 2004Blanka Rogina +2 more
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