Results 141 to 150 of about 372,846 (179)
Pharmacokinetic and Bioequivalence Evaluation of Two Sitagliptin Tablets With Different Salts in Healthy Subjects. [PDF]
Clin Pharmacol Drug DevHyun U +7 more
europepmc +1 more source
Biodegradable microneedles for transdermal sitagliptin delivery: in vivo insights into enhanced diabetes management. [PDF]
Drug Deliv Transl ResYehia RM +5 more
europepmc +1 more source
ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition. [PDF]
Mol MetabZheng Z +10 more
europepmc +1 more source
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Sitagliptin phosphate: A DPP-4 inhibitor for the treatment of type 2 diabetes mellitus
Clinical Therapeutics, 2007Sitagliptin phosphate, the first dipeptidyl peptidase 4 (DPP-4) inhibitor, provides a new treatment option for patients with type 2 diabetes.The purpose of this article is to review the pharmacology, pharmacokinetics, pharmacodynamics, clinical efficacy, adverse effects, and cost of sitagliptin in adults with type 2 diabetes.A literature search of ...
Tina, Zerilli, Eunice Y, Pyon
exaly +3 more sources
Biotechnology and Bioengineering, 2021
AbstractHere, we report a bienzymatic cascade to produce β‐amino acids as an intermediate for the synthesis of the leading oral antidiabetic drug, sitagliptin. A whole‐cell biotransformation using recombinant Escherichia coli coexpressing a esterase and transaminase were developed, wherein the desired expression level of each enzyme was achieved by ...
Mahesh D Patil +2 more
exaly +3 more sources
AbstractHere, we report a bienzymatic cascade to produce β‐amino acids as an intermediate for the synthesis of the leading oral antidiabetic drug, sitagliptin. A whole‐cell biotransformation using recombinant Escherichia coli coexpressing a esterase and transaminase were developed, wherein the desired expression level of each enzyme was achieved by ...
Mahesh D Patil +2 more
exaly +3 more sources
Bioorganic and Medicinal Chemistry Letters, 2007
A series of beta-aminoamides bearing triazolopiperazines has been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Efforts at optimization of the beta-aminoamide series, which ultimately led to the discovery of JANUVIA (sitagliptin phosphate, compound 1), are described.
Kathryn A Lyons +2 more
exaly +3 more sources
A series of beta-aminoamides bearing triazolopiperazines has been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Efforts at optimization of the beta-aminoamide series, which ultimately led to the discovery of JANUVIA (sitagliptin phosphate, compound 1), are described.
Kathryn A Lyons +2 more
exaly +3 more sources
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2015
Simple, specific, accurate and precise spectrophotometric methods were developed and validated for the simultaneous determination of the oral antidiabetic drugs; sitagliptin phosphate (STG) and metformin hydrochloride (MET) in combined pharmaceutical formulations.
Shereen Mowaka, Hayam Mahmoud Lotfy
exaly +3 more sources
Simple, specific, accurate and precise spectrophotometric methods were developed and validated for the simultaneous determination of the oral antidiabetic drugs; sitagliptin phosphate (STG) and metformin hydrochloride (MET) in combined pharmaceutical formulations.
Shereen Mowaka, Hayam Mahmoud Lotfy
exaly +3 more sources
Headspace gas chromatography for the determination of Isopropylamine in sitagliptin phosphate
Analytical Chemistry LettersXiao Hua Zhang, Zong Wen Pang
exaly +2 more sources
Hospital Pharmacy, 2007
Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and ...
Dennis J. Cada +2 more
openaire +1 more source
Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and ...
Dennis J. Cada +2 more
openaire +1 more source
In Vitro Study and Pharmacokinetic Evaluation of Sitagliptin Phosphate Enantiomers in Rat Plasma
Bioanalysis, 2023Background: A chiral HPLC technique was developed to determine sitagliptin phosphate enantiomers in rat plasma in compliance with US FDA regulations. Methods & results: The technique used a Phenomenex column with a mobile phase consisting of a 60:35:5 (v/v/v) blend of pH4, 10-mM ammonium acetate buffer, methanol and 0.1% formic acid in Millipore water.
Tatineni Spandana +2 more
openaire +2 more sources