Results 151 to 160 of about 372,846 (179)

Efficient stereocontrolled synthesis of sitagliptin phosphate

Tetrahedron: Asymmetry, 2014
Abstract The synthesis of sitagliptin phosphate 1 , a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from the chiral synthon (1,4-bis[( R )-1-phenylethyl]piperazine-2,5-dione) 2 , involving highly stereocontrolled (>98%) alkylation as a key step, in a good overall yield of 50% over six steps.
Chennam Setty Subbaiah, Wahajul Haq
openaire   +1 more source

Pharmacokinetics and relative bioavailability of sitagliptin hydrochloride and sitagliptin phosphate tablets formulations: a randomized, open-label, crossover study in healthy male volunteers

Generics and Biosimilars Initiative Journal, 2023
Introduction/Study Objectives: The present study aimed to evaluate the comparative bioavailability of a new generic sitagliptin formulation. Methods: This was an open label, randomized, balanced, two-sequence, two-treatment, two-period, single oral dose, crossover, bioequivalence (BE) study in 30 healthy male volunteers under fasting conditions.
Chuei Wuei Leong, Elton Sagim, Kar Ming Yee, Muhammad Shalhadi Saharuddin, Sharifah Radziah Syed Abd Rahim, Khairil Sabri, Mohd Zulhairi Jamaluddin, Shahnun Ahmad, Atiqah Amran, Rabab F Tayyem   +9 more
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Sitagliptin Phosphate Monohydrate

2011
Biological target: Sitagliptin is a β-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DPP4), a serine protease with membrane cell-signalling and soluble N-terminal proline peptidase activity. As a result, sitagliptin inhibits the in vivo degradation of the incretins, such as glucagon-like peptide-1 (GLP-1), which are endogenous glucoregulatory ...
Vitomir Šunjić, Michael J. Parnham
openaire   +1 more source

Synthesis of Sitagliptin Phosphate by a NaBH4/ZnCl2-catalyzed Diastereoselective Reduction

Chemistry Letters, 2015
Abstract A practical asymmetric synthesis of sitagliptin phosphate, from 1-{3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)butane-1,3-dione, in overall 65.3% yield has been reported. The target compound was synthesized via eneamination, diastereoselective reduction, amine-deprotection ...
Xianhua Pan, Kun Wang, Wansheng Yu, Ruimin Zhang, Lu Xu, Feng Liu   +5 more
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Quality by Design Based Analytical Method Development and Validation of Sitagliptin Phosphate by RP-HPLC

International Journal of Research in Pharmacy and Allied Science
The proposed RP- HPLC method using QbD approach provides simple accurate, and reproducible quality analysis for determination of Sitagliptin phosphate. 32 factorial design were used. study interaction of 2 factors were selected as dependent variables i.e mobile phase composition and flow rate and independent variables i.e retention time and tailing ...
Syed Aslam Hamid, Pallavi Patharkar, Umar Attar, Shaikh Md Moiz, Mohd Shoeb Nawaz   +4 more
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FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF SITAGLIPTIN PHOSPHATE

To optimize the clinical management of type 2 diabetes mellitus, this study focuses on the design, development, and comprehensive evaluation of immediate-release Sitagliptin oral tablets using diverse functional excipients and comparative manufacturing techniques.
openaire   +1 more source

Sitagliptin Phosphate

2021
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Sitagliptin Phosphate

2023
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Environmentally friendly protocol for the determination of sitagliptin phosphate in pharmaceutical preparations and biological fluids using l-tyrosine as a fluorescence probe

Luminescence, 2023
Muhammad N Khan
exaly  

Sitagliptin Phosphate

2022
openaire   +1 more source