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RISING STARS: Effects of a GLP-1 receptor polymorphism on responses to liraglutide. [PDF]
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In vitro study and pharmacokinetic evaluation of sitagliptin phosphate enantiomers in rat plasma.
Bioanalysis, 2023Background: A chiral HPLC technique was developed to determine sitagliptin phosphate enantiomers in rat plasma in compliance with US FDA regulations. Methods & results: The technique used a Phenomenex column with a mobile phase consisting of a 60:35:5 (v/
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Introduction/Study Objectives: The present study aimed to evaluate the comparative bioavailability of a new generic sitagliptin formulation. Methods: This was an open label, randomized, balanced, two-sequence, two-treatment, two-period, single oral dose,
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Headspace gas chromatography for the determination of Isopropylamine in sitagliptin phosphate
Analytical Chemistry LettersThe detection and control of residual solvents directly affect the product quality and safety. Isopropylamine is one of the raw materials of sitagliptin phosphate and so far its detection has not been reported.
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The primary objective of this study was to develop sitagliptin phosphate oral films that dissolve quickly in order to treat diabetic mellitus. The solvent casting method was employed to make the sitagliptin phosphate films that dissolve quickly.
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Introduction/Study Objectives: The aim of the current study is to assess the rate and extent of absorption of a test and reference formulation containing sitagliptin.
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