Results 101 to 110 of about 383,013 (128)

Investigation of the Effect of 70 Potential Interferents on Measurement Results of Two Blood Glucose Monitoring Systems. [PDF]

J Diabetes Sci Technol
Baumstark A, Pleus S, Mende J, Jendrike N, Tesar M, Schauer S, Sugiyama T, Aoki T, Sugiura M, Freckmann G, Haug C.   +10 more
europepmc   +1 more source

Synthesis and biological studies of 2-aminothiophene derivatives as positive allosteric modulators of glucagon-like peptide 1 receptor. [PDF]

Bioorg Med Chem
Campbell JA, Do P, Li Z, Malik F, Mead C, Miller N, Pisiechko C, Powers K, Li Z.   +8 more
europepmc   +1 more source

Sitagliptin Phosphate Monohydrate

, 2011
Biological target: Sitagliptin is a β-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DPP4), a serine protease with membrane cell-signalling and soluble N-terminal proline peptidase activity. As a result, sitagliptin inhibits the in vivo degradation of the incretins, such as glucagon-like peptide-1 (GLP-1), which are endogenous glucoregulatory ...
Michael J Parnham, Vitomir Sunjic
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Quantitative planner chromatographic method development for sitagliptin phosphate monohydrate and metformin hydrochloride in presence of their degradation product

Asian Journal of Research in Chemistry, 2015
This paper presents the stability indicating method for the simultaneous analysis of sitagliptin phosphate monohydrate and metformin hydrochloride using High Performance Thin Layer Chromatography (HPTLC) with densitometric detection. Separation of both the drugs was performed on silica gel G 60F254 plates with detection wavelength of 216 nm. The mobile
Sanjay G. Walode, Avinash V. Kasture
exaly   +2 more sources

Method Development and Validation of an AQbD-Based Gradient RP-HPLC Method for Simultaneous Estimation of Sitagliptin Phosphate Monohydrate and Simvastatin in a Synthetic Mixture

International Journal of Drug Delivery Technology
Aim & Objective: The present study aimed to develop and validate an AQbD-guided gradient RP-HPLC method for the simultaneous estimation of Sitagliptin Phosphate Monohydrate (SPM) and Simvastatin (SMV) in a laboratory-prepared synthetic mixture. A Central Composite Design (CCD) was employed to optimize chromatographic parameters, specifically buffer
Nandini P. Dhongade, Manish S. Kondawar, Javeed Manure   +2 more
openaire   +2 more sources

Solid-State Phase Transformation of Monohydrate and Anhydrous Form II of Sitagliptin Phosphate into a Novel Anhydrous Form IV – Solvent-Driven, Temperature-Induced and Stress Testings

Journal of Pharmaceutical Sciences
The solid form landscape of sitagliptin phosphate was systematically evaluated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy and X-ray powder diffraction (XRPD), supported by a plethora of auxiliary analytical techniques.
Nikola Geškovski, Petre Makreski, Jonathan B Lefton   +2 more
exaly   +3 more sources

Understanding the Adsorption and Desorption of Sitagliptin Phosphate Monohydrate on SS2343, Glass, and PTFE Using QCM-D and Raman Spectroscopy

Langmuir, 2022
Cross-contamination during pharmaceutical drug manufacturing can result in expensive recalls. To counter that, companies spend significant time and resources to ensure equipment cleanliness, often relying on the compound solubility data in various solvents as the main indicator of cleaning success.
Hui Ling Chan, Darrel Po Rong Len, Shuying Cheng, Jin Wang Kwek, Valerio Isoni, Beng Joo Reginald Thio   +5 more
openaire   +2 more sources

STABILITY INDICATING HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE AND SITAGLIPTIN PHOSPHATE MONOHYDRATE IN SYNTHETIC MIXTURE

Journal of Dynamics and Control
Rushi Pandya, Puja Vyas, Priyanka S. Patil, Banshri Gajjar, Chainesh N. Shah, Umesh Upadhyay   +5 more
exaly   +2 more sources

Development and Validation of Simultaneous Quantitative Dissolution Analysis for the Two Active Pharmaceutical Ingredients in Dapagliflozin Propanediol Monohydrate-sitagliptin Phosphate Monohydrate Multi-layered Tablets

Current Pharmaceutical Analysis, 2023
Background: Recently, a combination prescription with the main ingredients sitagliptin and dapagliflozin as dipeptidyl peptidase-4 andsodium–glucose cotransporter-2 inhibitors, respectively, for the treatment of type 2 diabetes has widely been issued in hospitals.
Ji-Hye Shin, Joo-Eun Kim
openaire   +1 more source

The Development and Validation of Simultaneous Quantitative Analysis Reversed-phase High-performance Liquid Chromatography for Sitagliptin Phosphate Monohydrate and Dapagliflozin Propanediol Monohydrate Fixed-dose Combination Dual-layered Tablet

Current Pharmaceutical Analysis, 2023
Background: Sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixeddose combination (FDC) dual-layered tablet is used for type 2 diabetes treatment. Simultaneous quantitative analysis can shorten the analysis time of sitagliptin phosphate monohydrate-dapagliflozin propanediol monohydrate FDC dual-layered tablets and increase their ...
So-Jin Kang, Joo-Eun Kim
openaire   +1 more source