Results 91 to 100 of about 2,793,666 (316)

Permanent displacement of slopes under multi-point earthquake ground motions considering site effects

Yantu gongcheng xuebao
The nonlinear dynamic response of slope soils caused by seismic motion may lead to inconsistent time histories of seismic acceleration at different positions of a slope.
SONG Jian1, 2 , PAN Yuhang2, LU Zhuxi2, JI Jian1, 2, ZHANG Fei1, 2, GAO Yufeng1, 2
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

End-Site-Specific Conjugation of Enoxaparin and Tetradeoxycholic Acid Using Nonenzymatic Glycosylation for Oral Delivery

, 2016
Heparin and low molecular weight heparins (LMWHs) have been the drug of choice for the treatment or the prevention of thromboembolic disease. Different methods are employed to prepare the LMWHs that are clinically approved for the market currently.
Kwangmeyung Kim (457840), Jooho Park (1497754), Jisuk Yun (3368012), Youngro Byun (1497748), Hwajung Nam (3368009), Jinha Hwang (792153), Taslim A. Al-Hilal (3351308), Ok Cheol Jeon (3368006), Kyungjin Kim (140317)   +8 more
core   +1 more source

An Investigation into Near-Fault Ground Motion Characteristics and Their Influence on the Seismic Response of Typical Girder Bridges

Buildings
Near-fault ground motions significantly threaten bridges due to their distinct features, which are often inadequately considered in current seismic codes based mainly on far-field records.
Lei Zhou, Jiangli Zhang, Xu Wang, Youjia Zhang, Xinbo Jiang, Lihua Chen, Chunmei Zheng   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optimization of Structural Design in Steel Buildings Based on the Site-Specific Design Spectra of the Mexico Seismic Regulations

Geosciences
Seismic risk management in urban areas requires accurate prediction of the expected seismic hazard. The seismic design standards in the world provide the seismic design spectra (DS).
Juan Antonio Ramos-Sánchez, Sergio A. Díaz, René Sebastián Mora-Ortiz, Gabriel Polanco-Sotomayor, Francisco Magaña-Hernández   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Development of Practical Wrist Rehabilitation Robot by Mirror Effect

, 2014
The authors have developed wrist rehabilitation robot for hemiplegic patients. The robot is much effective for repetitive rehabilitation, and useful for patients. Mirror effect control system is developed based on the experience that a patient can easily
Hachisuka, Kenji, Inagawa, Naohiro, Wada, Futoshi, Matsui, Miki, Yamamoto, Ikuo, Tsuji, Takunori, Hachisuka, Akiko   +6 more
core   +1 more source