Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Site effect estimation through site characterization from ambient noise recordings,
, 2010 Site effect assessment is an important step in seismic risk mitigation. There is therefore a drastic need for co proxies to site effects estimates. In that context, a new promising approach was proposed, using the time-avera over the top z meters with ...
Savvaidis, A. +6 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
How about integration: the impact of online activities on store satisfaction and loyalty
Although there has been widespread support for the concept of integrating the Internet with other channels, relatively little empirical research has been conducted in this area.
Teerling, Marije L.
core
Verification and validation of knowledge-based systems with an example from site selection. [PDF]
In this paper, the verification and validation of Knowledge-Based Systems (KBS) using decision tables (DTs) is one of the central issues. It is illustrated using real-market data taken from industrial site selection problems.One of the main problems of ...
Vanthienen, Jan, Wets, G, Witlox, Frank
core
Correction: A numerical study of site effect and dynamic response of staged excavation supported by soil nail walls. [PDF]
Sci RepMaleki M +2 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A numerical study of site effect and dynamic response of staged excavation supported by soil nail walls. [PDF]
Sci RepMaleki M +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Oxidative and Hydrolytic HNO Formation from a Clinical Drug Hydroxyurea Catalyzed by Horseradish Peroxidase: Basic Mechanism, Active Site Effect, and Implications for Drug Design. [PDF]
JACS AuMcCarthy E +3 more
europepmc +1 more source