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The effect of site-to-site variability in ultrasensitive dose responses

Journal of Mathematical Biology, 2016
In this paper we study the ultrasensitive behavior of multisite phosphorylation or ligand binding systems, under site-to-site variations in the modification rates. Using computational methods and mathematical analysis, we prove that the Hill coefficient reaches its maximum value when all sites are identical to each other.
Enciso, German A., Ryerson, Shane
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Site effect determination at liquefiable sites

Acta Geodaetica et Geophysica Hungarica, 2006
Soft surface sedimentary layers can considerably increase damages during earthquakes. This soil amplification can be computed with different analytical methods. At loose saturated sandy layers, where pore pressure increase and liquefaction are probable, the effective stress method is the appropriate tool to compute site response.
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Ecotoxicological effects at contaminated sites

Toxicology, 2004
Contamination sites pose significant environmental hazards for terrestrial and aquatic ecosystems. They are important sources of pollution and may result in ecotoxicological effects on terrestrial, groundwater and aquatic ecosystems. At severely contaminated sites, acute effects occur, but the core problem lies in long-term chronic effects ...
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Inductive Effect on Single-Atom Sites

Journal of the American Chemical Society, 2023
Single-atom catalysts exhibit promising electrocatalytic activity, a trait that can be further enhanced through the introduction of heteroatom doping within the carbon skeleton. Nonetheless, the intricate relationship between the doping positions and activity remains incompletely elucidated.
Chang-Xin Zhao   +12 more
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The Knowledge Leveling Effect of Portal Sites

Communication Research, 2014
The new high-choice media environment has allowed entertainment-oriented people to avoid political news, resulting in a wider gap in political knowledge between entertainment- and news-oriented citizens. On the Internet, however, users tend to be concentrated into a handful of portal sites that offer a mixed information environment in which both news ...
Tetsuro Kobayashi, Kazunori Inamasu
openaire   +1 more source

Midbrain as a Site for the Motion After-effect

Nature, 1969
Electrophysiological data for directionally sensitive units in optic tectum of mammals, indicating midbrain as site for rotating spiral motion ...
W, Richards, R A, Smith
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The site of action for the convulsant effect of pentylenetetrazol

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1981
Abstract 1. Lymnaea neutons demonstrated convulsive bursting in response to 40 mM pentylenetetrazol (PTZ) applied extracellularly but showed no response to injections calculated to bring intracellular concentrations of PTZ to 100 mM. 2. PTZ was found to permeate cell membranes. 3.
M F, Pacheco   +2 more
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Effects of Granuloma Formation at Site of Vasovasostomy

Journal of Urology, 1988
Spermatic granulomas forming after vasectomy reversal have been thought to mechanically compromise the anastomosis. We have studied the physiologic effects of vasectomy and vasovasostomy in rats. Following delayed microsurgical vasovasostomy, fluid flow through the anastomosis and cauda epididymidal hydrostatic pressure are not significantly different ...
P O, Carey   +6 more
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A model for monitoring Web site effectiveness

Internet Research, 1997
Presents a model which organizations can use to monitor Web site effectiveness. Argues that anecdotal evidence can be colorful but is not useful in structuring and managing an effective site. Suggests that traditional disciplines of composition and communication ‐ explicit purpose, coherent structure, relevant conclusion ‐ should be applied to Web site
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Effect of site of pacing on dispersion of refractoriness

The American Journal of Cardiology, 1985
The variation in dispersion of ventricular refractoriness with different sites of pacing was measured in 11 patients not taking antiarrhythmic drugs. Dispersion of refractoriness between 3 right ventricular sites was determined at constant paced cycle lengths (S1S1).
T D, Friehling   +3 more
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