Results 111 to 120 of about 2,410,081 (311)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A SYSTEMS APPROACH FOR EVALUATING ON-FARM SITE-SPECIFIC MANAGEMENT TRIALS: A CASE STUDY WITH VARIABLE RATE MANURE AND CROP QUALITY RESPONSE TO INPUTS

Site-specific application of manure has the potential to improve crop production and environmental quality. If manure is applied where it is needed, in the quantity required by the crop, over application, with attendant runoff and leaching problems can ...
Malzer, Gary L., Lambert, Dayton M., Lowenberg-DeBoer, James   +2 more
core  

The Influence of Seismic Parameters on Site Response

Civil Engineering Dimension, 2015
Geotechnical earthquake engineers have been trying to determine the most appropriate solution techniques for ground response analysis under earthquake loadings. This paper presents the importance of the adequate soil behavior model to simulate earthquake
Asakereh A., Jamali H., Naderi E.
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Publicly Funded Cleanups Site Status Report 2003

, 2005
The Publicly Funded Cleanups Site Status Report 2003 details efforts by the New Jersey Department of Environmental Protection's (NJDEP) Site Remediation and Waste Management Program to investigate and clean up contaminated properties using public funds.

core   +1 more source

Seismic site response in Siracusa

, 2015
In the frame of the Italo–Maltese research project (Costituzione di un Sistema Integrato di Protezione Civile Transfrontaliero Italo–Maltese, SIMIT), researches financially supported by the European Community were performed in the area between the south–eastern Sicilian coast and the islands of Lampedusa and Malta. Aim of these stud- ies is to mitigate
LOMBARDO, Giuseppe, PANZERA, FRANCESCO, D’AMICO S, GALEA P, SICALI S.   +4 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

PRECISION AGRICULTURE: ECONOMICS OF NITROGEN MANAGEMENT IN CORN USING SITE-SPECIFIC CROP RESPONSE ESTIMATES FROM A SPATIAL REGRESSION MODEL

Adapting variable rate technology (VRT) to Argentine conditions requires methods that use inexpensive information and that focus on the inputs and variability common to Argentine maize and soybean growing areas.
Lowenberg-DeBoer, James, Bongiovanni, Rodolfo   +1 more
core  

Site response analysis considering strain compatible site period

, 2016
In practice it is common to estimate site effects using a single proxy, or single variable such as 30 m shear wave velocity (VS30) or site period. Many studies have investigated merits of proposed proxies with contradicting recommendations.
Hayati, Hoss, Moss, Robb E.S.
core   +1 more source

Development of a site and motion proxy-based site amplification model for shallow bedrock profiles using machine learning

Frontiers in Built Environment
Accurate prediction of site amplification is crucial for seismic hazard assessment, particularly at shallow bedrock sites where limited data can constrain modeling efforts.
Yong-Gook Lee, Duhee Park, Oh-Sung Kwon
doaj   +1 more source