Results 131 to 140 of about 2,410,081 (311)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Estimating the Potential Value of Variable Rate Nitrogen Applications: A Comparison of Spatial Econometric and Geostatistical Models

Site-specific crop response functions (SSCRFs) are useful for estimating the value of variable rate nitrogen applications (VRA), but appropriate statistical models are necessary.
Malzer, Gary L., Oishi, Kikuo, Hurley, Terrance M.   +2 more
core  

Probability of Liquefaction for Pit Disassembly and Conversion Facility (PDCF) Site, Savannah River Site

, 2003
This report documents the probability of liquefaction (POL) for the Pit Disassembly and Conversion Facility (PDCF). The procedure for analysis of a critical layer of interest requires the following basic steps: (1) establish the probability of occurrence
Lee, R.C.
core   +1 more source

Nonlinear Site Response Analysis in District XIII, Budapest

Slovak Journal of Civil Engineering
Urban seismic hazard assessments must account for local soil conditions that can significantly alter ground motion characteristics. This study presents a nonlinear one-dimensional (1D) site response analysis for four locations within Budapest’s District ...
Al-Azazmeh Ahmad, Mahler András
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Donor site healing response to low-level laser therapy following skin graft surgery

Introduction Skin grafting is an essential reconstructive technique for the healing of deep and extensive burns. Donor site problems are common complications after skin graft surgery.
Salah Mohamed Abdelghani, Mahmoud Salah Salem, Haidy Nady Ashem, Noha Mohamed Kamel   +3 more
core   +1 more source

Volume growth responses of Scots pine and Norway spruce to nitrogen fertilization: quantitative synthesis of fertilization experiments in Finland

Silva Fennica
The effects of nitrogen (N) fertilization on tree growth have been studied widely in boreal forests in Finland, but a quantitative synthesis is still lacking.
Johanna Jetsonen, Annamari Laurén, Heli Peltola, Katariina Laurén, Samuli Launiainen, Marjo Palviainen   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

MANAGING PHOSPHOROUS SOIL DYNAMICS OVER SPACE AND TIME

Understanding the relationship between soil fertility dynamics and crop response is conceptually appealing. Even more appealing is comprehension of the spatial and temporal heterogeneity of these connections over a production surface and across seasons ...
Malzer, Gary L., Lambert, Dayton M., Lowenberg-DeBoer, James   +2 more
core  

Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study. [PDF]

J Clin Oncol, 2016
Bagatell R, McHugh K, Naranjo A, Van Ryn C, Kirby C, Brock P, Lyons KA, States LJ, Rojas Y, Miller A, Volchenboum SL, Simon T, Krug B, Sarnacki S, Valteau-Couanet D, von Schweinitz D, Kammer B, Granata C, Pio L, Park JR, Nuchtern J.   +20 more
europepmc   +1 more source