Results 141 to 150 of about 2,410,081 (311)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Implications of Image-Defined Risk Factors and Primary-Site Response on Local Control and Radiation Treatment Delivery in the Management of High-Risk Neuroblastoma: Is There a Role for De-escalation of Adjuvant Primary-Site Radiation Therapy? [PDF]
Int J Radiat Oncol Biol Phys, 2019 Lucas JT +11 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Group thermal response testing for energy piles
, 2015 Thermal response testing is an in situ technique for characterising the thermal conductivity of the ground around a borehole heat exchanger. The test has seen renewed interest in recent years as an increasing number of ground heat exchangers are being ...
Loveridge, F.A. +11 more
core
Site response analysis in performance based approach
A performance based approach for site response analysis requires a probabilistic approach accounting for the observed variability in soil stratification and engineering properties of the soil layers.
Tönük, G. +2 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
IS YIELD RESPONSE SITE-SPECIFIC? REVISITING NITROGEN RECOMMENDATIONS ON CORN
Replaced with revised version of paper 08/19/02.Crop Production/Industries,
Swinton, Scott M. +2 more
core
A Geospatial Model for Site Response Complexity
One-dimensional (1D) site response models assume vertically incident SH waves propagating through laterally uniform soil layers. These assumptions, collectively referred to as the SH1D model, are widely used in site-specific ground motion predictions ...
Kaklamanos, James +2 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source