Results 121 to 130 of about 2,410,081 (311)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
SITE-SPECIFIC VERSUS WHOLE-FIELD FERTILITY AND LIME MANAGEMENT IN MICHIGAN SOYBEANS AND CORN
Prior research into variable-rate application (VRA) of fertilizer nutrients has found profitability to be lacking in single nutrient applications to U.S. cereal crops.
Swinton, Scott M. +5 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The paper analyzes site-specific and uniform management options for wheat production with respect to grain quality. Besides site-specific fertilization the economic potential of segregation of different grain qualities is the subject of this paper. Yield
Weersink, Alfons +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Team structure evaluation of hazardous material emergency response teams in the Midwest [PDF]
, 2001 Plan BA formal plan to evaluate the success of hazardous materials emergency response teams did not exist at Eau Claire Fire Rescue. Problems with its own response team caused this agency to question whether team structure and makeup changes might ...
Kassing, Edward
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Response from David Meriwether to charges against him
Response from defendant, David Meriwether, Governor of New Mexico, in the District Court, County of Santa Fe, to charges against him by petitioners, James L. Collins and Preston Beck, Jr., for mandamus and bill for injunction.
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, 2006 In the present work I infer the 1D shear-wave velocity model in the volcanic area of Pozzuoli-Solfatara using the dispersion properties of both Rayleigh waves generated by artificial explosions and microtremor.
Petrosino, S., Petrosino, Simona
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source