Results 51 to 60 of about 2,410,081 (311)

Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

eLife, 2020
Splicing is a vital cellular process that modulates important aspects of animal physiology, yet roles in regulating innate immunity are relatively unexplored. From genetic screens in C.
Chun Kew, Wenming Huang, Julia Fischer, Raja Ganesan, Nirmal Robinson, Adam Antebi   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Explainable Machine Learning-Based Ground Motion Characterization: Evaluating the Role of Geotechnical Variabilities on Response Parameters

Geosciences
Accounting for geotechnical property variability is crucial in seismic site response analysis. Traditionally, the influence of each geotechnical property on response parameters is assessed independently. However, this approach limits our understanding of
Ayele Tesema Chala, Richard Ray, Mais Mayassah, Janko Logar, Edina Koch   +4 more
doaj   +1 more source

Mouse models of diffuse large B cell lymphoma

Frontiers in Immunology, 2023
Diffuse large B cell lymphoma (DLBCL) is a genetically highly heterogeneous disease. Yet, to date, the vast majority of patients receive standardized frontline chemo-immune-therapy consisting of an anthracycline backbone.
Areya Tabatabai, Aastha Arora, Svenja Höfmann, Maximilian Jauch, Bastian von Tresckow, Julia Hansen, Julia Hansen, Julia Hansen, Julia Hansen, Julia Hansen, Ruth Flümann, Ruth Flümann, Ruth Flümann, Ruth Flümann, Ruth Flümann, Ron D. Jachimowicz, Ron D. Jachimowicz, Ron D. Jachimowicz, Ron D. Jachimowicz, Ron D. Jachimowicz, Sebastian Klein, Hans Christian Reinhardt, Gero Knittel   +22 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evaluating Seismic Site Response in a Deep Alluvial Basin: The Case of the Bornova Basin (Izmir)

Gazi Üniversitesi Fen Bilimleri Dergisi
This research investigates the effects of deep alluvial basins in the Bornova region of Izmir on earthquake ground motion by combining field characterization with 1D and 2D equivalent linear soil response analyzes.
Hüseyin Akkuş , Nihat Sinan Işık
doaj   +1 more source

Site Specific Ground Response Analysis for Quantifying Site Amplification at A Regolith Site

Indonesian Journal on Geoscience, 2017
DOI: 10.17014/ijog.4.3.159-167A numerical model has demonstrated that it can simulate reasonably well earthquake motions at the ground level during a seismic event. The most widely used model is an equivalent linear approach.
Bambang Setiawan
doaj   +1 more source

Influence of thick soft superficial layers of seabed on ground motion and its treatment suggestions for site response analysis

Open Geosciences, 2021
The thick soft superficial layers of the seabed greatly influence ground motion generally. It is worth studying how to find out the influence of these soft layers on ground motion parameters and determine reasonable seismic fortification parameters for ...
Jiang Qifeng, Rong Mianshui, Wei Wei, Zhang Bin, Wang Jixin   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Developing Strategies for spatially variable nitrogen application in cereals, I: Winter barley [PDF]

, 2003
For precision agriculture to provide both economic and environmental benefits over conventional farm practice, management strategies must be developed to accommodate the spatial variability in crop performance that occurs within fields.
Welsh, J. P., Blackmore, S., Wood, G. A., Taylor, John C., Taylor, J. C., Earl, R., Godwin, R. J., Knight, S. M.   +7 more
core   +1 more source