Results 121 to 130 of about 2,089,094 (303)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
SITE-SPECIFIC VERSUS WHOLE-FIELD FERTILITY AND LIME MANAGEMENT IN MICHIGAN SOYBEANS AND CORN
Prior research into variable-rate application (VRA) of fertilizer nutrients has found profitability to be lacking in single nutrient applications to U.S. cereal crops.
Swinton, Scott M. +5 more
core
The influence of local site conditions on the site response analysis
, 2022 H.-G. Schmidt, F. Cigan
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Site amplification model for use in ground motion prediction equations [PDF]
, 2013 textThe characteristics of earthquake shaking are affected by the local site conditions. The effects of the local soil conditions are often quantified via an amplification factor (AF), which is defined as the ratio of the ground motion at the soil ...
Navidi, Sara
core
Analysis of Influence Characteristics of Site Conditions on Seismic Response of Utility Tunnel
BuildingsUtility tunnels are crucial infrastructure projects for cities. Earthquakes are a leading cause of damage to these tunnels. The effect of a non-homogeneous site, as a complex site, on the seismic response of utility tunnels cannot be ignored.
Konghao Wang +3 more
doaj +1 more source
Site-specific ground response analysis
, 2004 The local soil conditions have a profound influence on ground response during earthquakes. The recent destructive earthquakes have again demonstrated that the topography, nature of the bedrock and nature and geometry of the depositional soils are the primary factors thatinfluence local modifications to the underlying motion.
GovindaRaju, L +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2004 The Direct Boundary Element Method (DBEM) is presented to solve the elastodynamic field equations in 2D, and a complete comprehensive implementation is given. The DBEM is a useful approach to obtain reliable numerical estimates of site effects on seismic
Sánchez-Sesma, Francisco José +7 more
core +1 more source