Results 101 to 110 of about 30,097,494 (296)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

2D nonlinear seismic response characteristics of a megacity-scale site under Ricker wavelets

Scientific Reports
The seismic effects of complex, deep, and inhomogeneous sites constitute a significant research topic. Utilizing geological borehole data from the Suzhou urban area, a refined 2D finite element model with nonuniform meshes of a stratigraphic section ...
Wei Ren, Yan-Zhen Wang, Jiao Zhu, Ding-Feng Zhao, Qi Wu, Guo-Xing Chen   +5 more
doaj   +1 more source

SITE-SPECIFIC VERSUS WHOLE-FIELD FERTILITY AND LIME MANAGEMENT IN MICHIGAN SOYBEANS AND CORN [PDF]

Prior research into variable-rate application (VRA) of fertilizer nutrients has found profitability to be lacking in single nutrient applications to U.S. cereal crops.
Swinton, Scott M., Brook, Roger, Warncke, Darryl, Miller, Neil R., Jones, Kezelee Q., Schabenberger, O.   +5 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Seismic Site Response Analysis Using Spreadsheets [PDF]

, 2010
A spreadsheet-based framework for quantifying local site response due to seismic excitation is presented in this paper. The main focus here is on equivalent-linear one-dimensional analysis, similar to the computer program SHAKE or its derivative kin ...
Iglesia, Geraldo R., Stiady, James L.
core   +1 more source

Proposed Site-Specific Response Spectra for Surabaya-Madura Bridge

Civil Engineering Dimension, 2008
This paper presents a site-specific seismic hazard study to determine the recommended seismic design criteria for Suramadu Bridge. The study is performed using probabilistic seismic hazard approach to determine maximum acceleration and response spectra ...
Dyah Kusumastuti, R. Bambang Boediono, Hendriyawan Hendriyawan, Masyhur Irsyam, Donny T. Dangkua, Engkon K. Kertapati   +5 more
doaj