Results 101 to 110 of about 2,089,094 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
2D nonlinear seismic response characteristics of a megacity-scale site under Ricker wavelets
Scientific ReportsThe seismic effects of complex, deep, and inhomogeneous sites constitute a significant research topic. Utilizing geological borehole data from the Suzhou urban area, a refined 2D finite element model with nonuniform meshes of a stratigraphic section ...
Wei Ren +5 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Advance in seismic site response: Usual practices and innovative methods
, 2017 Amplitudes and frequency content of the seismic ground motion generated by an earthquake and recorded at a specific location depends on the characteristics of the source, the path from the source to the site and the local geologic conditions.
Panzera, Francesco +7 more
core +1 more source
Proposed Site-Specific Response Spectra for Surabaya-Madura Bridge
Civil Engineering Dimension, 2008 This paper presents a site-specific seismic hazard study to determine the recommended seismic design criteria for Suramadu Bridge. The study is performed using probabilistic seismic hazard approach to determine maximum acceleration and response spectra ...
Dyah Kusumastuti +5 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CRITICAL RADIONUCLIDE AND PATHWAY ANALYSIS FOR THE SAVANNAH RIVER SITE
, 2011 This report is an update to the analysis, Assessment of SRS Radiological Liquid and Airborne Contaminants and Pathways, that was performed in 1997. An electronic version of this large original report is included in the attached CD to this report.
Jannik, T., T. Jannik
core +1 more source
Analysis of Rayleigh wave dynamic response and propagation characteristics in layered site
Scientific ReportsRayleigh waves are crucial in earthquake engineering due to their significant contribution to structural damage. This study aims to accurately synthesize Rayleigh wave fields in both uniform elastic half-spaces and horizontally layered elastic half ...
Hao Lv
doaj +1 more source