Results 81 to 90 of about 2,089,094 (303)

Incorporating site response analysis and associated uncertainties into the seismic hazard assessment of nuclear facilities

, 2013
textThe development of a site-specific seismic hazard curve for a soil site requires the incorporation of site effects into the hazard calculation through the use of a site-specific amplification function.
Pehlivan, Menzer
core  

Dose Splitting Increases Selection for Both Target-Site and Non-Target-Site Fungicide Resistance—A Modelling Analysis [PDF]

Fungicide resistance management principles recommend that farmers avoid splitting the total dose applied of a fungicidal mode of action (MoA) across multiple applications per season (‘dose splitting’).
Shaw, M. W., Mikaberidze, A., Corkley, I., Paveley, N, Van Den Bosch, F., Milne, A. E.   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The apparent viscosity to model the behaviour of liquefied sands [PDF]

E3S Web of Conferences
The liquefaction induced loss of soil strength and stiffness marks a change of soil state, that switches from solid to liquid. Recently, the research has revealed that when liquefaction is attained, the soil behaves as a non-Newtonian fluid.
Mele Lucia, Lirer Stefania, Flora Alessandro   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Seismic Performance Assessment of an RC Building Due to 2023 Türkiye Earthquakes: A Case Study in Adıyaman, Türkiye

Buildings
The 7.7 and 7.6 magnitude Pazarcık and Elbistan earthquakes that struck Kahramanmaraş on 6 February 2023 caused widespread structural damage across many provinces and are considered rare in seismological terms.
Mahmut Bassurucu, Ozgur Yildiz, Ceren Kina   +2 more
doaj   +1 more source

Evaluation of coupled porewater pressure and stress-strain constitutive model in granular soils

Dyna, 2018
The evaluation of performance of three coupled pressure (PWP) generation models and stress-strain constitutive models are applied to granular soils. Those constitutive models are used to recommend them for subsequent application in seismic site-response ...
Oscar Moreno-Torres, Gustavo Chang-Nieto, Andrés Salas-Montoya   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source