Results 71 to 80 of about 30,097,494 (296)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nonlinear Site Response Analysis in District XIII, Budapest
Slovak Journal of Civil EngineeringUrban seismic hazard assessments must account for local soil conditions that can significantly alter ground motion characteristics. This study presents a nonlinear one-dimensional (1D) site response analysis for four locations within Budapest’s District ...
Al-Azazmeh Ahmad, Mahler András
doaj +1 more source
Dynamic analysis of underground structures with uncertain-but-bounded parameters
Case Studies in Construction MaterialsThe dynamic response of underground structures is significantly influenced by the uncertainties in soil and structural parameters, which cannot be neglected in seismic analysis.
Wenhao Zhang +3 more
doaj +1 more source
Connecticut State Emergency Response Commission [web site] [Harvested on 2011: Jun. 1]
, 2011 Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed June 1, 2011).; At head of title: State of Connecticut.; Official website of the Connecticut State Emergency Response Commission.
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Improvement of random vibration theory site response analysis [PDF]
, 2017 Random Vibration Theory (RVT) site response analysis is a standard in seismic hazard analysis for nuclear facilities to compute the dynamic response of soil deposits.
Wang, Xiaoyue, Ph. D.
core +2 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Evaluation of coupled porewater pressure and stress-strain constitutive model in granular soils
Dyna, 2018 The evaluation of performance of three coupled pressure (PWP) generation models and stress-strain constitutive models are applied to granular soils. Those constitutive models are used to recommend them for subsequent application in seismic site-response ...
Oscar Moreno-Torres +2 more
doaj +1 more source