Results 111 to 120 of about 2,089,094 (303)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

PRECISION AGRICULTURE: ECONOMICS OF NITROGEN MANAGEMENT IN CORN USING SITE-SPECIFIC CROP RESPONSE ESTIMATES FROM A SPATIAL REGRESSION MODEL

Adapting variable rate technology (VRT) to Argentine conditions requires methods that use inexpensive information and that focus on the inputs and variability common to Argentine maize and soybean growing areas.
Lowenberg-DeBoer, James, Bongiovanni, Rodolfo   +1 more
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A SYSTEMS APPROACH FOR EVALUATING ON-FARM SITE-SPECIFIC MANAGEMENT TRIALS: A CASE STUDY WITH VARIABLE RATE MANURE AND CROP QUALITY RESPONSE TO INPUTS

Site-specific application of manure has the potential to improve crop production and environmental quality. If manure is applied where it is needed, in the quantity required by the crop, over application, with attendant runoff and leaching problems can ...
Malzer, Gary L., Lambert, Dayton M., Lowenberg-DeBoer, James   +2 more
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Site-specific comparisons of random vibration theory-based and traditional seismic site response analysis

, 2006
textSeismic site response analysis is used to assess the effect of site-specific soil conditions on expected earthquake ground motions. For this purpose, input earthquake rock motions are propagated through a site-specific soil column to obtain motions
Ozbey, Mehmet Cem
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

One Dimensional Seismic Site Response Analysis of United Arab Emirates

, 2021
A Master of Science thesis in Civil Engineering by Ahmed Mohamed Zaroug Eltayeb entitled, “One Dimensional Seismic Site Response Analysis of United Arab Emirates”, submitted in August 2021. Thesis advisor is Dr. Magdi El-Emam and thesis co-advisor is Dr.
Eltayeb, Ahmed Mohamed Zaroug
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Enhancing Seismic Performance: A Comprehensive Study on Masonry and Reinforced Concrete Structures Considering Soil Properties and Environmental Impact Assessment

Advances in Civil Engineering
Approximately 20,000 people are killed annually on average by building and infrastructure collapses and failures caused by seismic activities. In earlier times, seismic design codes and specifications set minimal requirements for life safety performance ...
Benjamin Labar, Nurullah Bektaş, Orsolya Kegyes-Brassai   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Seismic Site Response Analysis Using Spreadsheets

, 2010
A spreadsheet-based framework for quantifying local site response due to seismic excitation is presented in this paper. The main focus here is on equivalent-linear one-dimensional analysis, similar to the computer program SHAKE or its derivative kin ...
Iglesia, Geraldo R., Stiady, James L.
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