Results 111 to 120 of about 30,097,494 (296)
Site-specific ground response analysis
, 2004 The local soil conditions have a profound influence on ground response during earthquakes. The recent destructive earthquakes have again demonstrated that the topography, nature of the bedrock and nature and geometry of the depositional soils are the primary factors thatinfluence local modifications to the underlying motion.
GovindaRaju, L +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Analysis of Rayleigh wave dynamic response and propagation characteristics in layered site
Scientific ReportsRayleigh waves are crucial in earthquake engineering due to their significant contribution to structural damage. This study aims to accurately synthesize Rayleigh wave fields in both uniform elastic half-spaces and horizontally layered elastic half ...
Hao Lv
doaj +1 more source
The influence of local site conditions on the site response analysis
, 2022 H.-G. Schmidt, F. Cigan
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Advances in Civil EngineeringApproximately 20,000 people are killed annually on average by building and infrastructure collapses and failures caused by seismic activities. In earlier times, seismic design codes and specifications set minimal requirements for life safety performance ...
Benjamin Labar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Estimating the Potential Value of Variable Rate Nitrogen Applications: A Comparison of Spatial Econometric and Geostatistical Models [PDF]
Site-specific crop response functions (SSCRFs) are useful for estimating the value of variable rate nitrogen applications (VRA), but appropriate statistical models are necessary.
Malzer, Gary L. +2 more
core