Results 121 to 130 of about 10,087,786 (356)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Media interventions and new social imaginaries [PDF]
, 2013 Recent re-articulations of the “social imaginary" (Castoriadis 1987) have emerged due to the proliferation and dispersion of new technologies in everyday life. What effect can enacting imaginative narratives for the near future have on present conditions?
Devereaux, Emile
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Analysis of data from test-well sites along the downdip limit of freshwater in the Edwards Aquifer, San Antonio, Texas, 1985-87 [PDF]
, 1994 George E. Groschen
openalex +1 more source
The Post-Apartheid Labour Market: 1995-2004 [PDF]
This paper seeks to investigate some of the changes that have occurred within the South African labour market in the post-apartheid era between 1995 and 2004 and some of the challenges the labour market presents in the attainment of shared growth ...
Morné Oosthuizen
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
InsectsDuring this research, the corn leaf aphids endosymbiotic bacterial diversity was tested in the same crop systems (monoculture industrial maize as grain for livestock) and the same soil type (Chernozem) when pre-crop pesticide management was used ...
Artúr Botond Csorba +5 more
doaj +1 more source