Results 71 to 80 of about 5,149,605 (295)

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Do Social Network Sites Enhance or Undermine Subjective Well‐Being? A Critical Review

open access: yes, 2017
Social network sites are ubiquitous and now constitute a common tool people use to interact with one another in daily life. Here we review the consequences of interacting with social network sites for subjective well-being—that is, how people feel moment-
Philippe Verduyn   +4 more
semanticscholar   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Typologie des espaces-frontières à l’heure de la globalisation

open access: yesBelgeo, 2013
This essay is a contribution to the theory of border effects, offering a synthetic vision in the form of a typology. It thematizes the changing nature of the role of borders and their spatial impact: from contiguous territories of traditional boundaries,
Remigio Ratti, Martin Schuler
doaj   +1 more source

Shanghai Experimental Free Trade Zone

open access: yesКонтуры глобальных трансформаций: политика, экономика, право, 2020
In 2013 the People’s Republic of China has entered the second stage of foreign economic openness. If at the first stage, which started in the late 1970s as an integral part of the overall reform policy, China focused primarily on attracting foreign ...
V. Ya. Portyakov
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

MRIQC: Advancing the automatic prediction of image quality in MRI from unseen sites

open access: yesbioRxiv, 2016
Quality control of MRI is essential for excluding problematic acquisitions and avoiding bias in subsequent image processing and analysis. Visual inspection is subjective and impractical for large scale datasets.
O. Esteban   +5 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

MatInspector and beyond: promoter analysis based on transcription factor binding sites

open access: yesBioinform., 2005
MOTIVATION Promoter analysis is an essential step on the way to identify regulatory networks. A prerequisite for successful promoter analysis is the prediction of potential transcription factor binding sites (TFBS) with reasonable accuracy.
Cartharius K   +9 more
semanticscholar   +1 more source

Counselling implications of teachers’ digital competencies in the use of Social Networking Sites (SNSs) in the teaching-learning process in Calabar, Nigeria

open access: yesCogent Education, 2016
The study investigated teachers’ digital competencies in the use of Social Networking Sites (SNSs) in the teaching-learning process. It had five research questions and two hypotheses. Adopting a survey design, it used a sample of 250 teachers from 10 out
Mfon Eyo
doaj   +1 more source

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