Results 91 to 100 of about 8,370,248 (313)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Sites ou pages web sur l’Espagne contemporaine
Cahiers de Civilisation Espagnole Contemporaine, 2022 doaj +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The tourist map, scientific tool that supports the exploration of protected areas, Bihor County, Romania [PDF]
GeoSport for Society, 2016 The study area is a Nature 2000 protected site from Bihor County, Romania. The present study aims at identifying the opportunities for the implementation of a bioeconomic exploitation system, by tourism development, according to its necessities for ...
Grigore Vasile HERMAN +6 more
doaj
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
ODP Sites 752&754 site-to-site correlation
The dataset was discussed in a chapter of my PhD thesis. The astronomically adjusted age model of ODP Site 752 has been published. However, the age-depth model of ODP Site 754 still needs to be updated. The fine-tuning step of the Site 754 age-depth model can be done by site-to-site correlation because carbon and oxygen stable isotope values between ...
openaire +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Late Bronze Age settlements in the Visun and the Lower Ingulets rivers basin
Tyragetia, 2020 This work continues the series of publications on Late Bronze Age sites published in the Tyragetia journal in 2018 and 2019. It significantly complements the archaeological map of the late Bronze Age sites of the Black Sea region.
Victor Grebennikov
doaj
J. Comput. Mediat. Commun., 2007 N. Ellison, C. Steinfield, Cliff Lampe
semanticscholar +1 more source