Results 71 to 80 of about 8,370,248 (313)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Coming together to define membrane contact sites
Nature Communications, 2019 Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell ...
L. Scorrano +14 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
InformationConventional spatiotemporal methods take frequentist or density-based approaches to map event clusters over time. While these methods discern hotspots of varying continuity in space and time, their findings overlook locations of routine occurrences where
Yanan Wu, Yalin Yang, May Yuan
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A local experience of ultrasonography in the diagnosis and treatment of tropical pyomyositis
International Journal of Medicine and Health Development, 2006 Background: Tropical pyomyositis is endemic in this environment yet a good number of patients with this condition are not detected on time.[1],[5],[19] Clinical diagnostic criteria are often misleading and recourse to imaging techniques would appear ...
Samuel O Mgbor
doaj
MRIQC: Advancing the automatic prediction of image quality in MRI from unseen sites
bioRxiv, 2016 Quality control of MRI is essential for excluding problematic acquisitions and avoiding bias in subsequent image processing and analysis. Visual inspection is subjective and impractical for large scale datasets.
O. Esteban +5 more
semanticscholar +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2022 Introdução: Dentre os transtornos alimentares (TAs), têm a anorexia nervosa (AN) e a bulimia nervosa (BN), que através de blogs e sites Pró-Ana e Pró-Mia presentes nas redes sociais, estão sendo vistos como um estilo de vida.
Marília Somaggio Souza +1 more
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