Results 171 to 180 of about 286,272 (317)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Improving Context-Aware Personalized Nudging: Using Wearable Sensors to Reduce Sedentary Behavior. [PDF]

Dela J Public Health
Rahman T, Vemuri A, Firkin CJ, Bodt B, Orsega-Smith E, Dominick GM, Decker K.   +6 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Sedentary behavior and stroke risk in US adults: The mediating role of central adiposity. [PDF]

Medicine (Baltimore)
Zhou Y, Zhao Q, Kang H, Li B, Chen A.
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Sit-to-stand and stand-to-sit transitions stimulate cardiac autonomic regulation and lead to age-dependent short-term patterns in heart rate. [PDF]

Front Physiol
Heidelbach MJ, Lange S, Edelhäuser F, Cysarz D.   +3 more
europepmc   +1 more source

PostureChair: A Real-Time, As-Needed Feedback System for Improving the Sitting Posture of Office Workers

, 2015
Jessica Speir
openalex   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Association between daily sitting time and osteoarthritis based on the National Health and Nutrition Examination Survey (NHANES) 2007 to 2018: A cross-sectional study. [PDF]

Medicine (Baltimore)
Chen Z, Wei W, Li R, Wang D, Tian Z, Feng Y, Wang D, Jia Z, Jiang J, Wang X, Ni J, Song Q, Shi Z.   +12 more
europepmc   +1 more source

New Measurement System for the Center of Gravity in Rehabilitation Medicine-Efficiency Test in Sitting [PDF]

, 1989
宗博 生田
openalex