Results 191 to 200 of about 407,599 (315)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Comparative analysis of lung function in supine and sitting positions in patients with moderate multiple sclerosis. [PDF]

Mult Scler J Exp Transl Clin
Wikars J, Kånåhols M, Nilsagård Y, Gunnarsson M, Westerdahl E.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Physical Activity and Sedentary Behaviour in the MEDIET4ALL Study: Associations with Mediterranean Lifestyle, Sleep, and Psychosocial Well-Being, with Mediation Analyses. [PDF]

Sports (Basel)
Ammar A, Salem A, Trabelsi K, Montalvan M, Bouaziz B, Boujelbane MA, Kerkeni M, Masmoudi L, Ghazzawi HA, Amawi AT, Orhan BE, Zambrano-Villacres R, Heydenreich J, Schallhorn C, Driss T, Frias-Toral E, Zmijewski P, Jahrami H, Husain W, Chtourou H, Schöllhorn WI.   +20 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Text Neck Joint Position Error Among Taibah University Students, Saudi Arabia-Cross-Sectional Design. [PDF]

Healthcare (Basel)
Mashabi A, Ragab WM, Aljohani SB, Aljohani RA, Almadani LA, Alsharif FA, Aburibiyyah JA, Aljohani MMA, Al-Shenqiti A.   +8 more
europepmc   +1 more source

Good sitting posture described

, 2015
Natural Posture While Sitting
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effects of Sitting Baduanjin on Cancer-Related Fatigue in Patients With Advanced Cancer: Protocol for a Randomized Controlled Trial. [PDF]

JMIR Res Protoc
Zhang Q, Chen X, Duan Y, Xie J, Chen Y, Hu Y, Cheng Q.   +6 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source