Results 61 to 70 of about 286,272 (317)

Traditional Ways of Sitting of Kalmyks (based on fi eld material )

open access: yesOriental Studies, 2018
The article is dedicated to the description of the traditional ways of sitting in accordance with age and social status.
Baira Mandzhieva
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Cerebral hemodynamic response to upright position in acute ischemic stroke

open access: yesFrontiers in Neurology
IntroductionConcerns exist that a potential mechanism for harm from upright activity (sitting, standing, and walking) early after an acute ischaemic stroke could be the reduction of cerebral perfusion during this critical phase.
Lilian B. Carvalho   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Evaluation of Office Chair Comfort

open access: yesDrvna Industrija, 2016
The studies of office chair constructions have identified differences in perception of comfort provided by different types of seats. Four seat constructions and the comfort provided to the users were compared by means of subjective indicators.
Zoran Vlaović   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Comparison of sedentary time, number of steps and sit-to-stand-transitions of desk-based workers in different office environments including working from home: analysis of quantitative accelerometer data from the cross-sectional part of the SITFLEX Study

open access: yesScandinavian Journal of Work, Environment & Health
OBJECTIVES: Sedentary behavior is associated with diseases (eg, cardiovascular, diabetes type 2). We aimed to describe the sitting and moving behavior of desk-based hybrid employees of a large company in Germany working in either a traditional open plan ...
Martha Sauter   +9 more
doaj   +1 more source

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